PRKAα1基因多态性与东亚人群胃癌易感性研究的meta分析

doi:10.3969/j.issn.1004-616x.2018.02.008

Abstract

Abstract: OBJECTIVE: To investigate the correlation of five single nucleotide polymorphisms in the PRKAα1 gene(rs13361707C > T,rs10074991G > A,rs154268T > C,rs3805486T > C and rs6882903C > A) with gastric cancer risk in an East Asian population. METHODS: Publications of correlation between PRKAα1 gene polymorphisms and gastric cancer were searched from PubMed,China National Knowledge Infrastructure (CNKI),Chinese Wan Fang database and Database of Chinese Scientific and Technical Periodicals (VIP). The odds ratios (OR) and 95% confidence intervals (95% CI),and sensitivity and publication bias were analyzed by STATA 12.0 software. RESULTS: The rs13361707C > T polymorphism analysis was mentioned in 9 studies. There was no significant association between rs13361707C > T polymorphism and gastric cancer risk in East Asian populations. The result of subgroup-analysis demonstrates:dominant model,OR=0.687,95% CI(0.614-0.769),P=0.000;recessive model,OR=0.662,95% CI(0.594-0.737),P=0.000; Addictive Model,OR=0.553,95% CI(0.484-0.632),P=0.000;codominant model,OR=0.766,95% CI(0.682-0.859), P=0.000;The subgroup analysis showed that this locus was associated with the decreased risk of gastric cancer in a Korean population under the four models. The rs10074991G > A polymorphism analysis was performed in 3 studies. The result of meta-analysis demonstrates:Dominant model,OR=0.590,95% CI(0.490-0.700),P=0.000;recessive model,OR=0.637,95% CI(0.535-0.759),P=0.000;addictive model,OR=0.478,95% CI(0.385-0.593),P=0.000; codominant model,OR=0.651,95% CI(0.541-0.784),P=0.000. The results show that this locus was associated with the decreased risk of gastric cancer in East Asian populations under the four genetic models. The subgroup analysis show that this locus was associated with the decreased risk of gastric cancer in Korean populations under the four genetic models. In addition to the recessive model,this locus was associated with the decreased risk of gastric cancer in Chinese populations under other three models. Three SNPs of rs154268T > C,rs3805486T > C,rs6882903C > A analysis were performed in 2 published studies. In addition to the recessive model,the rs154268T > C polymorphism was associated with the increased risk of gastric cancer in Korean populations under other three models. rs3805486T > C polymorphism was associated with the decreased risk of gastric cancer in Korean populations under the four genetic models. The rs6882903C > A polymorphism was associated with the increased risk of gastric cancer in Korean populations under the dominance and additive models. Begg's test found no publication bias (P > 0.05),sensitivity analysis showed that the above results were stable. CONCLUSION: The rs10074991G > A,rs154268T > C,rs3805486T > C and rs6882903C > A polymorphisms in PRKAα1 gene were significantly correlated with increased gastric cancer risk.

Key words: gastric cancer, PRKAα1, single nucleotide polymorphis, meta-analysis

CLC Number:

R730.2

YANG Meijuan, ZHANG Dong, FAN Wenjing, ZHANG Min, YOU Chongge. Correlation of PRKAα1 gene polymorphisms with gastric cancer risk in an East Asian population: A meta-analysis[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(2): 120-125,154.

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Correlation of PRKAα1 gene polymorphisms with gastric cancer risk in an East Asian population: A meta-analysis

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