XRCC3基因多态性与西北地区妇女乳腺癌的关联性研究

doi:10.3969/j.issn.1004-616x.2019.05.010

Abstract

Abstract: OBJECTIVE:To investigate correlations between gene polymorphisms and cancer,we studied polymorphisms in the XRCC3 double strand DNA repair gene in breast cancer. METHODS:Data on four gene loci (rs861534,rs861537,rs3212092 and rs861530) were combined with genotypes on breast cancer. High throughput chip detection assay was used for the polymorphism of XRCC3 in 517 cases of breast cancer and 1 008 disease-free controls which were collected in Gansu. RESULTS:With logistic regression analyses of the polymorphisms,rs861534 was found have significantly different distributions at the AG/AA genotype (P < 0.01,OR=0.36;P=0.013,OR=0.08) compared with the-GG-allele. The rs861530 AG+AA alleles-were significantly different from the controls (P=0.044). With respect to clinical indicators,the rs861537 GG/AG genotype was significant associated with positive ER protein (P=0.048,OR=1.50). In tumer tissues,the rs3212092 CT genotype was significantly associated with the Her-2⁺ protein (P=0.049),while the CC+CT genotype was significantly different (P=0.027,OR=2.06). CONCLUSION:Our results indicate that-XRCC3 rs861534 and rs861530-were significant associated with breast cancer risk. The GG/AG genotype with ER⁺ at XRCC3 rs861537 may impose a higher risk for breast cancer. Patients with the positive of ER protein and with the rs861537 locus may have increased risk from endocrine therapy. After adjusting for covariates,the rs3212092 homozygote TT-and heterozygote CT with Her-2⁺ expression were associated with the risk of recurrence and metastasis.

Key words: breast cancer, correlation analysis, single nucleotide polymorphisms, XRCC3 gene

CLC Number:

R730.2

WANG Lan, ZHANG Yongdong, GUO Hongyun, WANG Tao, WANG Haitao, GUO Huan, YANG Suisheng, LI Xiaoqin, SU Haixiang. Relationships between XRCC3 polymorphisms and breast cancer in northern Chinese women[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(5): 392-396,400.

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Relationships between XRCC3 polymorphisms and breast cancer in northern Chinese women

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