哈萨克族食管癌组织中miR-143、miR-145和Survivin mRNA的表达及其临床病理意义

doi:10.3969/j.issn.1004-616x.2020.01.005

Abstract

Abstract: OBJECTIVE: To explore the expression of miR-143,miR-145 and Survivin mRNAs,and their clinical significance in esophageal cancers among Kazaks in Xinjiang. METHODS: Expression levels of miR-143,miR-145 and Survivin mRNAs in 47 cases of Kazak esophageal cancer were detected by qPCR. RESULTS: The expression of miR-143 and miR-145 in cancer tissues was lower than that in the distal non-cancerous tissues,and the difference was significant (P < 0.01). On the other hand,survivin expression in cancer tissues was higher than that in the distal non-cancerous tissues (P=0.000). Expression of miR-143 was correlated with degree of differentiation,lymph node metastasis and clinical stages (P=0.018,0.004,0.022,respectively). Expression of miR-145 was correlated with degree of differentiation and lymph node metastasis (P=0.007,0.039,respectively). Expression of Survivin mRNA was correlated with lymph node metastasis and clinical stages (P=0.042,0.034,respectively). Expression of miR-143 was positively correlated with miR-145 (r=0.662,P=0.000),and negatively correlated with Survivin mRNA (r=-0.313,P=0.002). CONCLUSION: miR-143,miR-145,and Survivin mRNA are involved in the development and progression of Kazak esophageal cancer.

Key words: esophageal cancer, miR-143, miR-145, Survivin, Kazak

CLC Number:

R734.2

FENG Min, ABBIE·Mohetar, SHI Jingyi, ZUKELAI·Alijiang, LI Yongxiang, YAN Changshun, LI Xiumei. Expression of miR-143, miR-145 and Survivin mRNA in esophageal cancers among Kazaks[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(1): 29-32.

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Expression of miR-143, miR-145 and Survivin mRNA in esophageal cancers among Kazaks

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