2015—2019年某焦化厂下风向居民血清免疫球蛋白分析

doi:10.3969/j.issn.1004-616x.2022.01.003

Abstract

Abstract: OBJECTIVE: To compare serum immunoglobulin contents among different populations of residents in the downwind direction of a coking plant from 2015 to 2019 and to analyze changes in trends of abnormal rates. METHODS: In each summer from 2015 to 2019,residents from two villages in the downwind direction (1 to 2 km) of a coking plant in northern China were selected as the research group. They were recruited according to certain inclusion and exclusion criteria,and their blood and urine samples were collected to detect the contents of immunoglobulin (IgG,IgA and IgM) and urine creatinine (Cr) through an automatic biochemical analyzer. Abnormal rates of serum immunoglobulin contents were statistically analyzed. Contents of polycyclic aromatic hydrocarbon metabolite 1-hydroxypyrene in urine was detected by high performance liquid chromatography-fluorescence detection method. RESULTS: Among the research residents, the average serum IgG contents in women were higher than that of men for each year (P<0.01),and the average IgM contents were higher than that of men in 2015 and 2016 (P<0.05); The average serum IgG and IgA contents of adults were higher than those of minors in each year (P<0.01),while the average serum IgM content of adults was lower than that of minors in 2016 (P<0.01). In 2015-2019,the abnormal rates of serum immunoglobulin contents showed an overall upward trend and then a downward trend. There were significant differences in serum IgA and IgM between different years (P<0.01). And in 2016,the abnormal rates of serum IgG,IgA and IgM contents in adult were higher than those in minors (P<0.05). The abnormal rates of serum IgG contents in women were higher than that in men in 2015 and 2016 (P<0.05). In addition,from 2015 to 2019,the median detection levels of polycyclic aromatic hydrocarbon metabolite 1-hydroxypyrene in the urine of residents in this area were 0.468,0.797,0.678,0.169 and 0.021 μg/g,respectively. CONCLUSION: From 2015 to 2019,the serum immunoglobulin (IgG,IgA and IgM) levels of residents in the downwind direction of the coking plant showed certain gender and age differences,and their abnormal rates generally show an upward trend and then a downward trend.

Key words: serum immunoglobulin, 1-hydroxypyrene, abnormal rate, PAHs

CLC Number:

R392.7

GUO Yufeng, KONG Xiaona, ZHANG Ting, ZHANG Chao, XUE Zhenwei, LI Jianjun, ZHANG Jing, ZHOU Xiaolin. Analysis of serum immunoglobulins among residents in the downwind direction of a coking plant in from 2015 to 2019[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(1): 14-19.

References

[1] 李霄, 郑丹雪, 高晨, 等. 多环芳烃与苯对焦炉作业工人周围血血象和淋巴细胞DNA损伤影响[J]. 中国职业医学, 2015, 42(6):607-614.
[2] 邓华欣, 张望珍, 黄坤, 等. 焦化作业环境空气中颗粒物的污染特征研究[J]. 中华劳动卫生职业病杂志, 2012, 30(12):898-901.
[3] 赵慧, 高艳荣, 宋统球, 等. 焦炉工外周血IFN-γ表达及其DNA甲基化的分析[J]. 中国社区医师, 2019, 35(6):116-118.
[4] HEW K M, WALKER A I, KOHLI A, et al. Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells[J]. Clin Exp Allergy, 2015, 45(1):238-248.
[5] 程盼盼, 王炳玲, 崔瑛, 等. 多环芳烃暴露对免疫和神经发育影响[J]. 中国公共卫生, 2014, 30(10):1360-1362.
[6] 张婷, 周小林, 孟倩倩, 等. 多环芳烃暴露与儿童生长和免疫功能的关系:基于中国北部某焦化污染区的研究[J]. 环境与职业医学, 2020, 37(6):586-593.
[7] 孟倩倩, 李炜宾, 周小林, 等. 非污染区普通人群尿中多环芳烃羟基代谢产物初步调查[J]. 环境与健康杂志, 2016, 33(4):360-363.
[8] 孙冬雪, 张雪艳. 工作场所焦炉逸散物接触的健康风险评估[J]. 中国工业医学杂志, 2017, 30(4):315-316, 321.
[9] 王阳, 王一婧. 焦化厂职业暴露与肺癌关系研究进展[J]. 山西医药杂志, 2015, 44(9):1004-1005.
[10] 康美玉, 韩永霞, 高玉梅. 焦炉逸散物对作业工人红细胞免疫及调节功能的影响[J]. 现代预防医学, 2006, 33(3):413-414.
[11] 伯鑫, 王刚, 温柔, 等. 焦炉排放多环芳烃与人体健康风险评价研究[J]. 环境科学, 2014, 35(7):2742-2747.
[12] 牛红云, 蔡亚岐, 魏复盛, 等. 多环芳烃暴露的生物标志物:尿中羟基多环芳烃[J]. 化学进展, 2006, 18(10):1381-1390.
[13] GURBANI D, BHARTI S K, KUMAR A, et al. Polycyclic aromatic hydrocarbons and their quinones modulate the metabolic profile and induce DNA damage in human alveolar and bronchiolar cells[J]. Int J Hyg Environ Health, 2013, 216(5):553-565.
[14] DENG C, JIA M, WEI G, et al. Inducing optimal antitumor immune response through coadministering iRGD with pirarubicin loaded nanostructured lipid carriers for breast cancer therapy[J]. Mol Pharm, 2017, 14(1):296-309.
[15] 李先梅, 李力, 沈廷希, 等. 癌症病人血清免疫球蛋白检测结果[J]. 四川肿瘤防治, 1997, 10(1):10-11.
[16] 杨涛, 李佳, 张瑜. 恶性肿瘤患者血清免疫球蛋白检测结果分析[J]. 医学食疗与健康, 2020, 18(6):163-164.
[17] 王晓洪. 恶性肿瘤患者血清免疫球蛋白检测结果分析[J]. 中国民康医学, 2015, 27(1):83-84.
[18] JONGENEELEN F J, ANZION R B M, LEIJDEKKERS C M, et al. 1-Hydroxypyrene in human urine after exposure to coal tar and a coal tar derived product[J]. Int Arch Occup Environ Heal, 1985, 57(1):47-55.
[19] 高永生, 黄维星, 时丽秀. 不同年龄组血清中免疫球蛋白IgG、IgA、IgM的含量特点[J]. 中国冶金工业医学杂志, 2012, 29(5):497-498.
[20] 环境保护部. 国家环境保护"十二五"环境与健康工作规划:环发[2011] 105号[EB/OL]. (2011-09-20)[2021-08-10]. http://www.gov.cn/gongbao/content/2012/content_2112766.htm
[21] 环境保护部. 国家环境保护"十三五"环境与健康工作规划:环科技[2017] 30号[EB/OL]. (2017-02-22)[2021-08-10]. http://www.gov.cn/gongbao/content/2017/content_5222962.htm.
[22] 梁娇君, 毛革诗, 王冬明, 等. 2007-2014年武汉市职业性肿瘤情况分析[J]. 公共卫生与预防医学, 2016, 27(2):65-67.
[23] 范红敏. 职业性肺癌流行病学[J]. 职业卫生与应急救援, 2002, 20(3):164-167.
[24] 李淑岷, 张卫颖, 史春霞, 等. 焦炉工肺癌7例报告[J]. 中国工业医学杂志, 2013, 26(2):98-99.
[25] 万才珍, 崔彩岩, 刘克俭. 某焦化厂焦炉工人肺癌的发病特征[J]. 职业与健康, 2010, 26(19):2175-2177.

Analysis of serum immunoglobulins among residents in the downwind direction of a coking plant in from 2015 to 2019

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 2

Recommended Articles

Metrics

Comments

[1]	ZHANG Haiyan, LI Qingye, CHEN Shen, CHEN Wen, HE Zhini. Construction of an environmental pollution-responsive gene-specific pyrosequencing assay [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(2): 81-86.
[2]	PIAO Feng-yuan1, DUAN Zhi-wen2, ZHANG Yu-min2, CUI Jin-shan2, SUN Xian-ce1, YANG Guang1, YAMAUCHI Toru3,. Concentrations and Mutagenic Activities of Ambient Particulate Matter and Polycyclic Aromatic Hydrocarbons [J]. , 2007, 19(2): 143-146.