Dr. Yu Yingnian, pathophysiologist, graduated from Shanghai Medical University in 1954. He worked as a senior visiting scholar in Ontario Cancer Institute of Toronto University in 1989~1990. Now he is the professor of pathophysiology and supervisor of Ph.D. students in Zhejiang University School of Medicine. He was/is the member of the 3 provincial academic committees, 3 councils of international and whole China academic societies and 6 editorial boards of international and Chinese scientific journals. Since 1978, he starts his research work in the field of mechanism of mutagenesis induced by chemical carcinogens as well as the new assay technology of genotoxicity of chemicals and computer assisted structure-activity relationship analysis system (SARA) for prediction of the genotoxicity of chemicals; the molecular mechanism of non-targeted mutagenesis in mammalian cells; the kinetics of induction of CYP (cytochrome P450) gene expressions in cultured cell line, cloning and heterologous expression of cDNAs of carcinogen/drug metabolizing enzyme genes from Chinese. From 21st century on, he uses the rapid developed “-omic” technology in biologic research, i.e., the high throughput transcriptomic and proteomic techniques in the study of early response of human cells induced by representative environmental chemical pollutants (ECPs) as well as the function and expression control of relevant responsive genes/proteins. He bore responsibility for 22 National and 16 Provincial projects, and now is held responsible for a grant of National Key Basic Research and Developmental Program sponsored by National Ministry of Science and Technology; He published more than 180 refereed-papers and 13 academic books. He received 17 National and Provincial awards for his achievement in scientific research and once of Science and Technology Progress Award of Ho Leung Ho Lee Foundation as well as two honor titles from the State Council and Chinese Association of Science and Technology respectively.