口腔癌相关microRNA的研究进展

doi:10.3969/j.issn.1004-616x.2020.06.014

摘要/Abstract

摘要： MicroRNA（miRNA）表达失调与口腔癌（oral cancer）的发病机制有关。关于miRNA转化医学研究主要集中在精准肿瘤学上，旨在解码恶性肿瘤发生发展中的miRNA调控网络。miRNA的组织特异性表达和在体液中的稳定存在使其具有巨大的临床应用前景。最近对miRNA特性的研究使得它们成为恶性肿瘤诊断和预后的生物标记物，及将其作为新的治疗实体瘤的靶标，使口腔癌的个性化治疗成为可能。本文对口腔相关miRNA表达变化的临床意义，潜在的用于诊断和预后的miRNA生物标志物，以及靶向miRNA的治疗进行综述。

关键词: 口腔癌, microRNA, 生物标记物, 诊断, 预后, 靶向治疗

中图分类号:

R739.8

黎梓蕊, 许键, 李红文, 张鹏. 口腔癌相关microRNA的研究进展[J]. 癌变·畸变·突变, 2020, 32(6): 481-484.

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