癌变·畸变·突变 ›› 1998, Vol. 10 ›› Issue (5): 272-277.doi: 10.3969/j.issn.1004-616x.1998.05.002

• 论著 • 上一篇    下一篇

喉鳞癌组织中Bcl - 2 和P53 蛋白表达及意义

周晓蓉1 　吴　坤1 　韩多吉2 　赵瑞波3   

  1. 1哈尔滨医科大学公卫学院毒理教研室　哈尔滨　150001 2黑龙江省肿瘤医院头颈外科　　3 哈尔滨医科大学病理教研室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1998-09-30 发布日期:1998-09-30

THE EXPRESSION OF BCL - 2 、P53 PROTEIN IN LARYNGEAL SQUMAOUS CELL CARCINOMA AND ITS SIGNIFICANCE

Zhou Xiaorong1 , Wu Kun1 , Han Duoji2 , Zhao Reibo3   

  1. 1Dpartment of Heal th Toxicology , Public Heal th College , Harbin Medical University , Harbin 150001 2Heilongjiang province Tumor hospital 3Department of pathology , Harbin Medical University
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-09-30 Published:1998-09-30

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摘要： 为了探讨bcl - 2、P53 在喉鳞癌组织中的表达情况、预后的意义,我们应用免疫组化LSAB 法对53 例喉鳞状上皮细胞癌组织进行bcl - 2、P53 基因蛋白表达的测定。结果显示: (1) 47. 17 %的喉癌中检出突变型p53 蛋白,在部分喉癌癌旁不典型增生上皮中可见P53 蛋白表达,癌旁组织细胞已发生P53 基因突变可能是术后复发的根源,突变型P53 蛋白过度表达是喉癌发生的早期事件。P53 蛋白表达与较低的病理学分级、较高的核分裂数有关( P < 0. 05 , P < 0. 01) ,P53 蛋白表达阳性者肿瘤组织坏死例数高于P53 表达阴性者( P <0. 01) ,P53 蛋白表达阳性者生存期低于P53 表达阴性者,P53 表达与淋巴结转移及患病年龄无关,对判断肿瘤的恶性程度、预测肿瘤分化及预后有较高实用价值。(2) 喉鳞癌组织中bcl - 2 蛋白表达与较低的核分裂数及较小的患病年龄有关( P < 0. 05 , P < 0. 05) ,而与病理学分级、组织坏死、淋巴结转移及患者存活期无关,没有独立的预后价值。

关键词: Bcl - 2, P53, 免疫组织化学, 喉癌, 预后

Abstract: In order to study the expression of bcl - 2 , p53 protein in laryngeal squmaous cell carcinoma (LSCC) , the prognostic significance , their expression in 53 cases with laryngeal squmaous cell carcinoma were determinded by immunohistochemical LSAB method. The result s showed that : (1) In 47. 17 %LSCC , the expression of mutant p53 protein were positive. Meanwhile , mutant p53 protein was also expressed in some dysplastic epitheliumes near the cancer tissues. These epithelial cells near the tumor in which p53 gene has been altered , probably are the source of tumor recurrence , the expression of mutant p53 protein may be the early event s in the development of LSCC. The p53 protein expression was associated with low histological grade of differentiation , high mitotic count ( ( P < 0. 05 , P < 0. 01) . The necrosis in tumors with the p53 positive was higer than those with the P53 negative LSCC( P < 0. 01) ,patient s with p53 - positive LSCC had shorter survival times than patient s with p53 - negative LSCC. p53 protein expression was not associated with node status and age , is valuable in determinding the degree of malignancy , predicting tumor differentiation (2) In LSCCs , bcl - 2 expression was consistently low and related with low mitotic count and younge age ( P < 0. 05 , P < 0. 05) ,and bcl - 2 expression was not related with histological grade of differentiation , necrosis , node status and survival time.

Key words: bcl - 2, p53, Immunohistochemist ry, laryngeal carcinoma, prognosis

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