关键词: 醋氨己酸锌, 突变, 致畸作用

Abstract: This paper reported the research result s of mutagenicity and teratogenicity effect of zinc acexamatie.The result showed that zinc acexamatie with doses level (1 - 5000μg/ plate) did not induce positive mutations of st rains TA97 、TA98 、TA100 and TA102 with or without S9mix in Ames test . It was divided into three groups of Zinc acexamatic received (po) dosages of 32. 97mg/ kg. body weight , 262. 34mg/ kg. body weight , 524. 67mg/ kg.body weight on the 6th to 15th day of gestation mouse respectively in the teratogenic test . The f requency of live fetuses of each dose group were no significant difference as compared with solvent cont rol group. It did not cause deformity of the fetus appearances , bone and internal organs. But there were significant differences between solvent cont rol group and 524. 67mg/ kg group in the growth of body weight in gestation of mouse , body weight and tail length in fetus. The result showed that zinc acexamatie possess maternal toxicity and embryotoxicity.

Key words: zinc acexamatie, mutation, teratogenic effect s