癌变·畸变·突变 ›› 1999, Vol. 11 ›› Issue (5): 268-272.doi: 10.3969/j.issn.1004-616x.1999.05.024

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小剂量受照人员免疫功能变化的随访观察

吕玉民　傅宝华　邵志良　陈玉浩　韩　林　赵风玲   

  1. 河南省职业病防治研究所　郑州　450052
  • 收稿日期:1999-05-06 修回日期:1999-08-02 出版日期:1999-09-30 发布日期:1999-09-30

FOLLOWING2UP OBSERVATION FOR THE CHANGE OF THE IMMUNOLOGIC FUNCTION IN 26 CASES EXPOSED TO LOW2DOSE RADIATION

Lu Yumin , Fu Baohua , Shao Zhiliang , et al   

  1. Henan Instit ute of Occupational Disease , Zhengz hou 　450052
  • Received:1999-05-06 Revised:1999-08-02 Online:1999-09-30 Published:1999-09-30

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摘要： 对26 例小剂量受照人员受照26 - 31 年后,血清IgG、IgA 和IgM 的变化,淋巴细胞转化率,CD4 、CD8 和NK细胞阳性率进行了分析。结果表明,受照组体液免疫功能变化与对照组没有明显差异;CD4 、CD8 和NK细胞阳性率明显低于对照组,而CD4/ CD8 细胞比值明显高于对照组;淋巴细胞转化率亦低于对照组,差异接近显著。提示小剂量照射对机体细胞免疫功能具有一定的抑制作用。

关键词: 小剂量照射, 免疫功能, 随访观察

Abstract: The content of serum IgG、IgA and IgM , T Lymphocyte t ransformlation rate , and the positive rate of CD4 、CD8 and N Kcell were performed in 26 cases exposed low2dose radiation in 1966 and in 1971. The results indicated that the content s of serum IgG、IgA and IgM in the irradiated group were not more different than thatin cont rol ( P > 0. 05) ; the positive rates of CD4 、CD8 and N K cell were significantly lower ( P < 0. 05 , P < 0.01) , the value of CD4/ CD8 was much higher ( P < 0. 01) , the lymphocyte t ransformlation rate was lower (0. 05< P < 0. 01) in irradiared group than in cont rol. It is suggested the low2dose radiation can inhibit the cellular immune responses of the irradiated persons.

Key words: Low-dose radiation, Immunological funtion, Following2up observation

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