热休克蛋白27和三叶因子Ⅱ在胃癌中的表达及与幽门螺杆菌感染关系的研究

doi:10.3969/j.issn.1004-616x.2009.05.012

癌变·畸变·突变 ›› 2009, Vol. 21 ›› Issue (5): 380-383.doi: 10.3969/j.issn.1004-616x.2009.05.012

热休克蛋白27和三叶因子Ⅱ在胃癌中的表达及与幽门螺杆菌感染关系的研究

荣　芳1;侯　恒1;王　勇2;王满贵2;李丽芬1

1. 大同大学医学院内科教研室，山西　大同　037008； 2. 大同市第五人民医院，山西　大同 037006

收稿日期:2009-03-17 修回日期:2009-06-02 出版日期:2009-09-30 发布日期:2009-09-30
通讯作者: 荣　芳

The Expressions of HSP27 and TFF2 in Gastric Cancer and Correlations with H. pylori Infection

RONG Fang1; HOU Heng1; WANG Yong2;WANG Man-gui2; LI Li-fen1

1.Department of Medicine, Medical College, Datong University in Shanxi, Datong 037008; 2. Department of Pathology,The Fifth People's Hospital of Datong, Datong 037006, Shanxi, China

Received:2009-03-17 Revised:2009-06-02 Online:2009-09-30 Published:2009-09-30
Contact: RONG Fang

摘要/Abstract

摘要： 背景与目的：探讨热休克蛋白27(heat shock protein27, HSP27)、三叶因子Ⅱ(trefoil factors2, TFF2)在胃癌和癌前病变组织中的表达及其与幽门螺杆菌(helicobacter pylori, Hp)感染的关系。材料与方法：选取经病理证实的慢性浅表性胃炎、胃溃疡、慢性萎缩性胃炎和胃癌4种不同胃黏膜病变的标本共140例，用免疫组化法检测标本中HSP27和TFF2的表达及幽门螺杆菌的感染情况，分析HSP27和TFF2的表达与幽门螺杆菌感染的关系。结果：除TFF2在胃癌组织中表达降低外，在慢性浅表性胃炎、胃溃疡、慢性萎缩性胃炎和胃癌中，HSP27、TFF2的表达率和Hp的感染率依次呈逐渐增加的趋势。Hp感染组HSP27的表达率高于阴性组，HSP27的阳性表达率与Hp感染率之间呈正相关(r=0.235， P<0.05)，Hp感染组TFF2的表达率低于阴性组，TFF2的阳性表达率与Hp感染率之间呈负相关(r=－0.259， P<0.05)。结论： HSP27、TFF2表达和Hp感染与胃癌的发生密切相关，检测这些指标可为胃癌诊断、预后判断和指导治疗提供依据。

关键词: 热休克蛋白27, 三叶因子Ⅱ, 幽门螺杆菌

Abstract: BACKGROUND AND AIM： To investigate the expressions of heat shock protein 27(HSP27) and trefoil factors2 (TFF2) in gastric cancer and precancerous condition and its correlation with helicobacter pylori(Hp) infection. MATERIALS AND METHODS： The expressions of HSP27 and TFF2 and the infection of Hp were studied by immunohistochemical methods in 140 gastric specimens including 25 chronic superficial gastritis(CSG), 30 gastric ulcer (GU), 35 chronic atrophic gastritis (CAG) and 50 gastric cancers (GC). RESULTS： In CSG,GU,CAG and GC, the expressions of HSP27,TFF2 and Hp were increased, but the expression of TFF2 was decreased in gastric cancer. The expression of HSP27 in Hp positive group was significantly higher than that in negative group. The expression of HSP27 was positively correlated with the infection of Hp (r=0.235,P<0.05).The expression of TFF2 in Hp positive group was significantly decreased compared with that in negative. The expression of TFF2 was negatively correlated with Hp infection (r=－0.259,P<0.05). CONCLUSION： HSP27,TFF2 and Hp may play important roles in carcinogenesis and progression of gastric carcinoma. The evaluation of HSP27 and TFF2 and Hp could provide theoretical basis for diagnosing, evaluating prognosis and guiding treatment of gastric cancer.

Key words: heat shock protein 27, trefoil factors2, helicobacter pylori

中图分类号:

R735.2

荣　芳, 侯　恒, 王　勇, 王满贵, 李丽芬. 热休克蛋白27和三叶因子Ⅱ在胃癌中的表达及与幽门螺杆菌感染关系的研究[J]. 癌变·畸变·突变, 2009, 21(5): 380-383.

RONG Fang, HOU Heng, WANG Yong, WANG Man-gui, LI Li-fen. The Expressions of HSP27 and TFF2 in Gastric Cancer and Correlations with H. pylori Infection[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2009, 21(5): 380-383.

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热休克蛋白27和三叶因子Ⅱ在胃癌中的表达及与幽门螺杆菌感染关系的研究

The Expressions of HSP27 and TFF2 in Gastric Cancer and Correlations with H. pylori Infection

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