关键词: DAPK1, RARβ, 甲状腺癌, 免疫组织化学, 表达

Abstract: To investigate the expressions of death-associated protein kinase-1(DAPK1) and retinoic acid receptor beta (RARβ) in different thyroid carcinoma tisssues and clinicopathological significance in thyroid cancer． METHODS: S-P immunity histochemistry was used to detect DAPK1,RARβ in 38 thyroid carcinomas (PTC), 21 thyroid adenomas，13 Hashimoto’s thyroiditis , 6 nodular goiters and 6 peri-tumor tissue. RESULTS: The positive rate of DAPK1 in PTC was significantly lower than those in thyroid adenoma, Hashimoto’s thyroiditis, nodular goiters and peri-tumor tissue(P<0.01). The positive rate of RARβ in PTC was significantly higher than those in thyroid adenoma, Hashimoto’s thyroiditis, nodular goiters and peri-tumor tissue (P<0.01). CONCLUSION: As an apoptotic agent, DAPK1 may function as an inhibitor of tumor, and low DAPK1 gene expression may be involved in the oncogenesis of PTC. The detection of DAPK1 expression may be helpful for assessing metastasis and prognosis of PTC. RARβ expression was significantly higher in PTCs than that in benign thyroid lesions，and this characteristics can be of important value in diagnosis.

Key words: death-associated protein kinase-1, retinoic acid receptor beta, thyroid carcinoma, immunity histochemistry, expression