›› 2012, Vol. 24 ›› Issue (5): 340-344.doi: 10.3969/j.issn.1004-616x.2012.05.004

• 论著 • 上一篇    下一篇

卷烟烟气中4-N-亚硝基甲基氨-1-(3-吡啶基)-1-丁酮的量化健康风险评估

尚平平;李翔;聂聪;郭军伟;赵乐;刘惠民;谢剑平;陈小玉   

  1. ( 1. 郑州烟草研究院，河南 郑州 450001；2. 郑州大学公共卫生学院，河南 郑州 450000 )
  • 收稿日期:2012-06-29 修回日期:2012-08-30 出版日期:2012-09-30 发布日期:2012-09-30
  • 通讯作者: 聂聪

Quantitative health risk assessment of 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone in cigarette smoke

SHANG Ping-ping;LI Xiang;NIE Cong;GUO Jun-wei;ZHAO Le;LIU Hui-min;XIE Jian-ping;CHEN Xiao-yu   

  1. (1. Zhengzhou Tobacco Research Institute, Zhengzhou 450001; 2. Public Health Institute of Zhengzhou University, Zhengzhou 450000, Henan, China)
  • Received:2012-06-29 Revised:2012-08-30 Online:2012-09-30 Published:2012-09-30
  • Contact: NIE Cong

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摘要： 目的： 对卷烟烟气中4-N-亚硝基甲基氨-1-(3-吡啶基)-1-丁酮 (NNK)进行量化健康风险评估，为化合物的风险评估提供新的思路和方法。方法：运用健康风险评估基本框架，采用模拟与风险分析方法，对暴露参数进行概率分布模拟，并采用不同风险分析方法对NNK的风险进行评估。结果：采用二维和一维模拟得到NNK的风险评估终生癌症风险增量(ILCR)值分别为6.66×10-4和1.29×10-4， 其致癌风险需引起关注，并给予管控，灵敏度分析表明NNK释放量对风险影响较大。结论：NNK的释放量对致癌风险贡献较高，需引起高度关注。

关键词: 卷烟烟气, 4-N-亚硝基甲基氨-1-(3-吡啶基)-1-丁酮, 量化健康风险评估

Abstract: OBJECTIVE: To provide the new insight into the quantitative health risk assessment on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in cigarette smoke. METHODS：Using the basic frame of health risk assessment and simulation and risk analysis，the probability distribution of exposure parameters were fitted，NNK incremental lifetime cancer risk(ILCR) was simulated by 2D simulation and 1D simulation. RESULTS：ILCR values，the calculated risks of NNK，were 6.66×10-4 and 1.29×10-4，and NNK should be highly controlled. And NNK release exerted a great influence on ILCR. CONCLUSION：We should be highly concerned about NNK and its carcinogenic risk.

Key words: cigarette smoke, 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone, quantitative health risk assessment

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