Notch1在腺样囊性癌组织中的表达及其对预后的影响

doi:10.3969/j.issn.1004-616x.2013.02.014

癌变·畸变·突变

Notch1在腺样囊性癌组织中的表达及其对预后的影响

赵华¹,张凯^1，*,江磊²,汪国文²

1. 蚌埠医学院第一附属医院口腔科，安徽蚌埠 233000；2. 蚌埠医学院第一附属医院胸心外科，安徽蚌埠 233000

收稿日期:2012-10-10 修回日期:2013-01-21 出版日期:2013-03-30 发布日期:2013-03-30
通讯作者: 张凯，E-mail：zk9788@yahoo.com.cn
作者简介: 赵华 (1985- )，女，江苏镇江人，硕士研究生，研究方向：口腔颌面肿瘤。Tel：18725525710；E-mail：zhaohuaxiong_163@ 163.com
基金资助:
安徽省自然科学基金项目 (KJ2007B361ZC)

The expression and prognostic impact of Notch1 in adenoid cystic carcinoma andthe study of prognosis

ZHAO Hua¹，ZHANG Kai^1，*，JIANG Lei²，WANG Guo-wen²

1. Department of Stomatology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000; 2. Department of Cardiothoracic Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui, China

Received:2012-10-10 Revised:2013-01-21 Online:2013-03-30 Published:2013-03-30
Contact: ZHANG Kai，E-mail：zk9788@yahoo.com.cn

摘要/Abstract

摘要：

目的：探讨腺样囊性癌 (adenoid cystic carcinoma，ACC)组织中Notch1的表达，分析其表达与临床病理资料间的关系及其对预后的影响。方法：运用免疫组化方法检测38例ACC患者及对照组正常口腔小涎腺中Notch1的表达，并对ACC病例进行随访，分析Notch1的表达与临床病理资料间的关系及其对预后的影响。结果：ACC病例组中Notch1总阳性率为81.6% (31/38)，而正常口腔小涎腺阳性率为30% (9/30)，Notch1在ACC及正常口腔小涎腺中的表达差异具有统计学意义 (P<0.05)。Notch1的表达与病理分型、T分期及侵犯相邻组织呈正相关 (r =0.550，P=0.002；r =0.741，P=0.001；r =0.523，P=0.005)。单因素分析显示：病理分型、淋巴结转移、Notch1的表达、T分期、侵犯相邻组织对患者的预后有影响 (P<0.05)，且Notch1的表达和肿瘤分期是影响患者预后的独立危险因素。结论：ACC生长缓慢，但易复发且伴远处转移，Notch1在ACC的发生和发展中起重要作用，在评估其预后方面起一定作用。

关键词: Notch1, 腺样囊性癌, 预后, 免疫组织化学

Abstract:

OBJECTIVE: To investigate the expression of Notch1 in adenoid cystic carcinoma，and analyze the relationship between its expression with clinicopathologic characteristics and its impact on prognosis. METHODS： Using immunohistochemistry to assess Notch1 expression in 38 patients with adenoid cystic carcinoma (ACC) and normal small oral glands，follow-up information and to analyze the relationship between Notch1 expression and clinicopathological data and its impact on prognosis. RESULTS：The positive rates of Notch1 expression in ACC and normal small oral gland were 81.6% and 30%，respectively (P<0.05)，and Notch1 expression was positively correlated with pathological type，T stage and infringement of adjacent tissue (r=0.550，P=0.002；r=0.741， P=0.001；r=0.523， P=0.005). Pathological type，lymph node metastasis，expression of Notch1，T stage， infringement of adjacent tissue were related to survival，as determined via single survival analysis. Notch1 expression and tumor stage were independent prognostic factors for ACC patients. CONCLUSION：Adenoid cystic carcinoma growes slowly with easy relapse，the expression of Notch1 may play an important role in development of ACC，and has potential value in prognostic evaluation.

Key words: Notch1, adenoid cystic carcinoma, prognosis, immunohistochemistry

赵华,张凯,江磊,汪国文. Notch1在腺样囊性癌组织中的表达及其对预后的影响[J]. 癌变·畸变·突变, doi: 10.3969/j.issn.1004-616x.2013.02.014.

ZHAO Hua1，ZHANG Kai1，*，JIANG Lei2，WANG Guo-wen2. The expression and prognostic impact of Notch1 in adenoid cystic carcinoma andthe study of prognosis[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2013.02.014.

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Notch1在腺样囊性癌组织中的表达及其对预后的影响

The expression and prognostic impact of Notch1 in adenoid cystic carcinoma andthe study of prognosis

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