甲钴胺代谢遗传缺陷与基因组稳定性的研究进展

doi:10.3969/j.issn.1004-616x.2017.06.015

癌变·畸变·突变 ›› 2017, Vol. 29 ›› Issue (6): 479-482.doi: 10.3969/j.issn.1004-616x.2017.06.015

• 综述 • 上一篇

甲钴胺代谢遗传缺陷与基因组稳定性的研究进展

刘桥刚¹, 汪旭^1,2, 杨国防³, 周滔¹, 倪娟^1,2

1. 云南师范大学生命科学学院, 云南昆明 650500;
2. 云南师范大学生物能源持续开发与利用教育部工程研究中心, 云南昆明 650500;
3. 上海三誉生物科技有限公司, 上海 201100

收稿日期:2017-03-01 修回日期:2017-10-17 出版日期:2017-11-30 发布日期:2017-11-30
通讯作者: 倪娟,E-mail:gt_gg30@163.com E-mail:gt_gg30@163.com
作者简介:刘桥刚,E-mail:937542858@qq.com。
基金资助:
国家自然科学基金（31260268，31560307）

Received:2017-03-01 Revised:2017-10-17 Online:2017-11-30 Published:2017-11-30

摘要/Abstract

摘要： 甲钴胺（MeCbl）是哺乳动物细胞内的内源性维生素B12，其作为甲硫氨酸合成酶（MS）的辅酶，参与甲硫氨酸（Met）和内源性甲基供体S-腺苷甲硫氨酸（SAM）的合成，是一碳单位代谢的关键组分。SAM参与多种大分子物质的甲基化反应如DNA、RNA、蛋白质，是表观遗传调控的重要组分。因此，MeCbl对于甲基供体化合物的形成、基因表达、蛋白质活性和基因组稳定性的维持具有重要作用。本文就MeCbl代谢相关酶与蛋白质的遗传突变或多态性及其对基因组稳定性的研究进展进行简要综述。

关键词: 维生素B12, 甲钴胺, 代谢遗传缺陷, 一碳单位代谢, 基因组稳定性

中图分类号:

R394.6

刘桥刚, 汪旭, 杨国防, 周滔, 倪娟. 甲钴胺代谢遗传缺陷与基因组稳定性的研究进展[J]. 癌变·畸变·突变, 2017, 29(6): 479-482.

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甲钴胺代谢遗传缺陷与基因组稳定性的研究进展

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