外界刺激下肿瘤细胞中早反应基因5相关生物学功能的研究进展

doi:10.3969/j.issn.1004-616x.2018.02.016

癌变·畸变·突变 ›› 2018, Vol. 30 ›› Issue (2): 158-160.doi: 10.3969/j.issn.1004-616x.2018.02.016

外界刺激下肿瘤细胞中早反应基因5相关生物学功能的研究进展

赵现哲¹, 丁立新¹, 刘晓丹², 周平坤², 姜晓燕¹, 丁库克¹

1. 中国疾病预防控制中心辐射防护与核安全医学所放射生态研究室, 北京 100088;
2. 军事医学科学院放射与辐射医学研究所, 北京 100850

收稿日期:2017-01-13 修回日期:2017-09-29 出版日期:2018-03-30 发布日期:2018-03-30
通讯作者: 丁库克,E-mail:shouding@ccum.edu.cn;姜晓燕,E-mail:fangsheshengtai@126.com E-mail:shouding@ccum.edu.cn;fangsheshengtai@126.com
作者简介:赵现哲,E-mail:1241069549@qq.com
基金资助:
国家自然科学基金资助项目（30770533，31170806，31640022，31770907）；北京市自然科学基金资助项目（7092013，7172146）

Received:2017-01-13 Revised:2017-09-29 Online:2018-03-30 Published:2018-03-30

摘要/Abstract

摘要： 早反应基因5（IER5）属于早期反应基因，因其在多种肿瘤细胞中均发挥着抑制肿瘤细胞增殖的作用而受到广泛关注。在受到外界刺激（热压力、血清、电离辐射等）时，肿瘤细胞内的IER5会过表达从而使细胞作出一系列应激性反应如G2期周期阻滞和凋亡等。在临床放化疗中IER5的表达量可以作为一种潜在的肿瘤放化疗后诱导细胞凋亡的生物标记物，并和肿瘤组织大小相关，对今后放化疗方案的改进具有重要的指导意义。

关键词: 早期反应基因, 周期阻滞, 凋亡, 生物标记物

中图分类号:

R730.55

赵现哲, 丁立新, 刘晓丹, 周平坤, 姜晓燕, 丁库克. 外界刺激下肿瘤细胞中早反应基因5相关生物学功能的研究进展[J]. 癌变·畸变·突变, 2018, 30(2): 158-160.

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外界刺激下肿瘤细胞中早反应基因5相关生物学功能的研究进展

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