CREB在食管鳞癌组织中的表达及其临床意义

doi:10.3969/j.issn.1004-616x.2020.05.010

癌变·畸变·突变 ›› 2020, Vol. 32 ›› Issue (5): 387-390,394.doi: 10.3969/j.issn.1004-616x.2020.05.010

CREB在食管鳞癌组织中的表达及其临床意义

郭秀娟¹, 杜彦艳¹, 颜晰¹, 赵学涛², 韩丽娜², 武一鹏¹, 王雪晓³, 马鸣¹

1. 河北医科大学第四医院检验科, 河北石家庄 050011;
2. 河北医科大学第四医院输血科, 河北石家庄 050011;
3. 河北医科大学第四医院肿瘤免疫科, 河北石家庄 050011

收稿日期:2020-04-19 修回日期:2020-09-07 出版日期:2020-10-01 发布日期:2020-10-12
通讯作者: 马鸣,E-mail:maming19830419@163.com E-mail:maming19830419@163.com
作者简介:郭秀娟,E-mail:guoxiujuan69@126.com。
基金资助:
国家自然科学基金（81703073）；河北省自然科学基金（H2018206 115）

Expression and clinical significance of CREB in esophageal squamous cell carcinoma tissues

GUO Xiujuan¹, DU Yanyan¹, YAN Xi¹, ZHAO Xuetao², HAN Lina², WU Yipeng¹, WANG Xuexiao³, MA Ming¹

1. Department of Laboratory, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050011;
2. Transfusion Department, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050011;
3. Department of Tumor Immunity, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China

Received:2020-04-19 Revised:2020-09-07 Online:2020-10-01 Published:2020-10-12

摘要/Abstract

摘要： 目的：研究环磷腺苷效应元件结合蛋白（CREB）在食管鳞状细胞癌（ESCC）组织中的表达及其与患者临床特征、预后之间的关系。方法：选取2010年1—12月在河北医科大学第四医院就诊的60例ESCC患者癌组织及癌旁组织，采用Western blot及免疫组化技术检测组织中CREB蛋白的表达水平，并分析其与临床病理指标及患者预后之间的关系。结果：ESCC组织中CREB表达水平较癌旁组织明显升高（P < 0.01）。组织中CREB高表达的患者往往瘤组织较大、临床分期较晚、更易发生淋巴结转移，同时患者5年总生存率较低而累积复发率较高（P < 0.05）。结论：ESCC组织中CREB表达水平明显升高，且高表达CREB的患者往往提示临床进展及较差预后。因此，CREB具有成为ESCC相关肿瘤标志物的潜力。

关键词: 环磷腺苷效应元件结合蛋白, 食管鳞状细胞癌, 临床进展, 预后

Abstract: OBJECTIVE: To study the expression of cAMP-response element binding protein (CREB), in esophageal squamous cell carcinoma (ESCC) tissues,and its relationship with clinical characteristics and prognosis of the patients. METHODS: Samples of tumor tissues and paraplastic tissues were collected from 60 cases of the ESCC patients from January to December,2010. Expression of CREB in both tissues and their relationships with the clinical feathers of the patients were analysed by using Western blotting and Immunohistochemical assays. RESULTS: The tumor tissues showed significantly increased expression of CREB protein,compared with the paraplastic tissues (P < 0.01). Among patients,those with higher CREB expression tended to have large tumors,later clinical stages,higher lymph node metastasis and shorter five-year overall survival rate with higher cumulative recurrence rate (P < 0.05). CONCLUSION: The ESCC tissues showed significantly elevated expression of CREB protein. Furthermore,the patients with higher CREB expression in tumor tissues frequently had worse clinical outcomes and poorer prognoses. Therefore,CREB has the potential to be an ESCC-associated tumor marker.

Key words: CREB, ESCC, clinical progression, prognosis

中图分类号:

R735.1

郭秀娟, 杜彦艳, 颜晰, 赵学涛, 韩丽娜, 武一鹏, 王雪晓, 马鸣. CREB在食管鳞癌组织中的表达及其临床意义[J]. 癌变·畸变·突变, 2020, 32(5): 387-390,394.

GUO Xiujuan, DU Yanyan, YAN Xi, ZHAO Xuetao, HAN Lina, WU Yipeng, WANG Xuexiao, MA Ming. Expression and clinical significance of CREB in esophageal squamous cell carcinoma tissues[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(5): 387-390,394.

参考文献

[1] CHEN W, ZHENG R, BAADE P D, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016, 66(2):115-132.
[2] HAN J, LI E, CHEN L, et al. The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1[J]. Nature, 2015, 524(7564):243-246.
[3] STEVEN A, SELIGER B. Control of CREB expression in tumors:from molecular mechanisms and signal transduction pathways to therapeutic target[J]. Oncotarget, 2016, 7(23):35454-35465.
[4] DOBROFF A S, WANG H, MELNIKOVA V O, et al. Silencing cAMP-response element-binding protein (CREB) identifies CYR61 as a tumor suppressor gene in melanoma[J]. J Biol Chem, 2009, 284(38):26194-26206.
[5] YANG X X, MA M, SANG M X, et al. BMI-1 suppression increases the radiosensitivity of oesophageal carcinoma via the PI3K/Akt signaling pathway[J]. Oncol Rep, 2018, 39(2):667-678.
[6] SANG M, HULSURKAR M, ZHANG X, et al. GRK3 is a direct target of CREB activation and regulates neuroendocrine differentiation of prostate cancer cells[J]. Oncotarget, 2016, 7(29):45171-45185.
[7] CHEN Z, LI J L, LIN S, et al. cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth[J]. J Clin Invest, 2016, 126(6):2267-2279.
[8] ZHANG Y, ZHENG D, ZHOU T, et al. Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers[J]. Nat Commun, 2018, 9(1):4080.
[9] GLOUSHANKOVA N A. Changes in regulation of cell-cell adhesion during tumor transformation[J]. Biochemistry (Mosc), 2008, 73(7):742-750.
[10] VOROPAEV H, GIMMELSHEIN VATKIN M, SHNEOR D, et al. Infectious knockdown of CREB and HIF-1 for the treatment of metastatic uveal melanoma[J]. Cancers, 2019, 11(8):1056.
[11] CHEN P, LI M M, HAO Q Y, et al. Targeting the overexpressed CREB inhibits esophageal squamous cell carcinoma cell growth[J]. Oncol Rep, 2017, 39(3):1369-1377.

[1]	彭友彬, 林浩, 黎明, 黄海花. TPX2在非肌层浸润性膀胱癌中的表达及其临床意义[J]. 癌变·畸变·突变, 2022, 34(1): 30-34.
[2]	焦文鹏, 侯琳, 崔妹娟, 焦文静, 马鸣, 张金艳. miR-93-5p和miR-106b-5p在酒精相关性肝癌中的表达及其临床意义[J]. 癌变·畸变·突变, 2021, 33(6): 430-434.
[3]	高晓斌, 武雪亮, 王胜杰, 孙光源, 王文静, 梁峰, 赵轶峰, 刘振显, 张迎春. TRIM59在结直肠癌中的表达及其与临床病理指标的关系[J]. 癌变·畸变·突变, 2021, 33(6): 446-450.
[4]	焦文静, 张金艳, 马鸣, 郭秀娟, 冯军花, 邵俊国, 焦文鹏. 异黏蛋白与叉头框蛋白M1在肝细胞癌中的表达及其临床意义[J]. 癌变·畸变·突变, 2021, 33(5): 349-353,359.
[5]	张世民, 赵瑞君. 蛋白酪氨酸磷酸酶受体J在乳腺癌组织中的表达及其与临床预后的相关性[J]. 癌变·畸变·突变, 2021, 33(4): 276-279,285.
[6]	刘晓霞, 李卫霞, 李志加, 苏镇军, 段晓辉, 韩维文, 王云晓, 贺晓磊, 吕林林, 贾金海. 血清谷胱甘肽过氧化物酶与晚期非小细胞肺癌患者临床病理指标及预后的相关性[J]. 癌变·畸变·突变, 2021, 33(4): 286-290,295.
[7]	张玉铃, 吴俊东, 潘东岳, 陈春发. 乳腺癌新辅助化疗前后Ki67变化对疗效及预后的意义[J]. 癌变·畸变·突变, 2021, 33(3): 230-235,245.
[8]	李玮玮, 朱莹. 数据挖掘分析MYB家族在乳腺癌中的表达及其预后评估价值[J]. 癌变·畸变·突变, 2020, 32(6): 414-422.
[9]	石海林, 何天基, 刘峰, 蔡孟会, 葛波. 基于TCGA数据库分析肿瘤突变负荷在肌层浸润性膀胱癌预后评估中的价值[J]. 癌变·畸变·突变, 2020, 32(6): 430-437,443.
[10]	丁雅雯, 焦文静, 王芃堉, 鹿刚, 马鸣. 多发性骨髓瘤患者浆细胞免疫表型特点及其临床意义研究[J]. 癌变·畸变·突变, 2020, 32(6): 464-468,489.
[11]	黎梓蕊, 许键, 李红文, 张鹏. 口腔癌相关microRNA的研究进展[J]. 癌变·畸变·突变, 2020, 32(6): 481-484.
[12]	邵俊国, 焦文静, 王雪晓, 张金艳, 马鸣. miR-429和Bmi-1 mRNA在肺癌组织中的表达及其临床意义[J]. 癌变·畸变·突变, 2020, 32(5): 369-373.
[13]	吕燕萍, 吴传城, 杨双凤, 何陈周, 韩仁杰, 颜伟, 刘宝英. 胃癌差异表达miRNA及其相关基因的单核苷酸多态性与胃癌预后的相关性研究[J]. 癌变·畸变·突变, 2020, 32(5): 380-386.
[14]	朱依青, 张彤彤, 郑珺文, 郝佳洁, 蔡岩, 王明荣, 梁建伟, 张钰. p-mTOR蛋白在结直肠癌组织中的表达及患者预后判断中的价值[J]. 癌变·畸变·突变, 2020, 32(3): 161-165.
[15]	杨丽, 张孟贤, 张微, 熊英友, 陈世勇, 方呈祥. 基于数据挖掘分析极光激酶A在食管癌中的表达及意义[J]. 癌变·畸变·突变, 2020, 32(3): 221-228.

CREB在食管鳞癌组织中的表达及其临床意义

Expression and clinical significance of CREB in esophageal squamous cell carcinoma tissues

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价