邯郸市女性高危型HPV感染情况分析

doi:10.3969/j.issn.1004-616x.2023.05.009

癌变·畸变·突变 ›› 2023, Vol. 35 ›› Issue (5): 382-386.doi: 10.3969/j.issn.1004-616x.2023.05.009

邯郸市女性高危型HPV感染情况分析

董志玲¹, 王志刚¹, 姚利¹, 陈朝英², 胡敏³, 王蕾¹

1. 邯郸市中心医院, 河北邯郸 056002;
2. 邯郸市中西医结合医院, 河北邯郸 056005;
3. 邯郸市中心医院新兴院区, 河北邯郸 056300

收稿日期:2023-05-11 修回日期:2023-09-20 发布日期:2023-10-13
通讯作者: 王蕾
作者简介:董志玲,E-mail:mytf_ling@163.com。
基金资助:
邯郸市科学技术研究与发展计划项目(19422083009-14)

Analysis of high-risk HPV infection results in Handan

DONG Zhiling¹, WANG Zhigang¹, YAO Li¹, CHEN Chaoying², HU Min³, WANG Lei¹

1. Handan Central Hospital, Handan 056002;
2. Handan Hospital of Integrated Chinese and Western Medicine, Handan 056005;
3. Xinxing Hospital Area of Handan Central Hospital, Handan 056300, Hebei, China

Received:2023-05-11 Revised:2023-09-20 Published:2023-10-13

摘要/Abstract

摘要： 目的： 分析邯郸市宫颈癌筛查女性中17种高危型HPV亚型感染情况、年龄分布情况及年度感染趋势。方法： 收集2014年1月1日—2021年12月31日期间在邯郸市中心医院行宫颈癌筛查的64 317例女性患者高危型HPV 的感染情况，分析其总感染率、型别分布、年龄感染率分布以及年度趋势。结果： 接受宫颈癌筛查的64 137例女性患者中，共检出高危型HPV阳性16 096例，高危型感染率为25.1%，以单一型别感染为主，单一型感染率为73.9%(11 902/16 096例)，双重及多重感染率为26.1%(4 194/16 096例)。感染率排名前5位的亚型分别为HPV16(16.5%)、HPV52(14.5%)、HPV58(10.5%)、HPV53(7.9%)、HPV51(7.2%)。按年龄分组高危型HPV感染率最高为≤20岁年龄组，感染率为70.6%；其次为≥60年龄组，感染率为29.4%。单一型高危型HPV感染率最高的年龄组为41~50岁，感染率构成比为77.8%，多重型高危型HPV感染率构成比最高的年龄组为≤20岁，感染率构成比为39.1%，各年龄组单一型和多重型高危型HPV感染率构成比间的差异均有统计学意义(P<0.01)。2014—2021各年度高危型HPV感染率呈下降趋势(P<0.01)。结论： 邯郸市女性高危型HPV 感染率较高，常见亚型为HPV16、HPV52、HPV58、HPV53、HPV51，且随年龄呈 U 型分布，2014—2021 各年度感染率随时间呈下降趋势。HPV 的流行学特征可以帮助指导 HPV 疫苗接种和宫颈癌筛查。

关键词: 人乳头瘤病毒, 宫颈癌筛查, 基因分型, 年度趋势

Abstract: OBJECTIVE:To analyze the prevalence,age distribution and annual infection trend of 17 high-risk HPV subtypes in Handan. METHODS: The high-risk HPV results of 64 317 female patients who came to Handan Central Hospital for cervical cancer screening from January 1,2014 to December 31,2021 were collected. The overall prevalence, distribution types, age-specific prevalence and annual trends were analyzed. RESULTS: Among 64 137 female patients screened for cervical cancer,16 096 were positive for high-risk HPV, with an overall high-risk infection rate of 25.1%, with 11 902(73.9%) of single type infection,and 4 194(26.1%) of double or more types of multiple infection. The top five subtypes of infection rate were HPV16,HPV52,HPV58,HPV53 and HPV51,accounting for 16.5%,14.5%,10.5%,7.9% and 7.2% of the positive items respectively. The highest infection rate of high-risk HPV was ≤ 20 years old,with the infection rate of 70.6%,followed by ≥ 60 years old,with the infection rate constituent ratio of 29.4%. The age group with the highest infection rate of single high-risk HPV was 41-50 years old, and the constituent ratio of infection rate was 77.8%. The age group with the highest infection rate of multiple severe high-risk HPV in each age group was ≤ 20 years old,and the constituent ratio of infection rate was 39.1%. The infection rate of single high-risk HPV and multiple severe high-risk HPV in each age group was statistically different (P<0.01). The annual high risk HPV infection rate showed a downward trend (P<0.01). CONCLUSION: The infection rate of high-risk HPV among women in Handan was high. The common subtypes of high-risk HPV infection were HPV16,HPV52,HPV58,HPV53,and HPV51.And the distribution was U-shaped with age.According to the analysis,the annual infection rate showed a downward trend from 2014 to 2021. The prevalent characteristics of HPV should help to guide HPV vaccinations and cervical cancer screenings.

Key words: human papillomavirus, cervical cancer screening, genotype, annual trend

中图分类号:

Y737.33

董志玲, 王志刚, 姚利, 陈朝英, 胡敏, 王蕾. 邯郸市女性高危型HPV感染情况分析[J]. 癌变·畸变·突变, 2023, 35(5): 382-386.

DONG Zhiling, WANG Zhigang, YAO Li, CHEN Chaoying, HU Min, WANG Lei. Analysis of high-risk HPV infection results in Handan[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2023, 35(5): 382-386.

参考文献

[1] 赵敬, 杨金豪, 张文帆, 等. 2009-2020年中国女性生殖道支原体、衣原体和人乳头瘤病毒感染与宫颈癌发生相关性的Meta分析[J]. 天津医科大学学报, 2021, 27(4):396-400.
[2] ZHAI Q Z, ZHANG W Y, ZHANG Z, et al. Characteristics of the cervicovaginal microenvironment in childbearing-age women with different degrees of cervical lesions and HR-HPV positivity[J]. Pol J Microbiol, 2021, 70(4):489-500.
[3] ZHANG J Y, CHENG K Y, WANG Z L. Prevalence and distribution of human papillomavirus genotypes in cervical intraepithelial neoplasia in China:a meta-analysis[J]. Arch Gynecol Obstet, 2020, 302(6):1329-1337.
[4] 胡尚英, 赵雪莲, 张勇, 等.《预防宫颈癌:WHO宫颈癌前病变筛查和治疗指南(第二版)》解读[J]. 中华医学杂志, 2021, 101(34):2653-2657.
[5] TRAMA J P, TRIKANNAD C, YANG J J, et al. High-risk HPV genotype distribution according to cervical cytology and age[J]. Open Forum Infect Dis, 2022, 9(11):ofac595.
[6] ZHAO S, ZHAO X L, HU S Y, et al. Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China[J]. Chin J Cancer Res, 2019, 31(4):663-672.
[7] HUANG J, YIN C S, WANG J L. Relationship between vaginal microecological changes and oncogene E6/E7 and high-risk human papillomavirus infection[J]. J Obstet Gynaecol, 2023, 43(1):2161349.
[8] LUAN H P. Human papilloma virus infection and its associated risk for cervical lesions:a cross-sectional study in Putuo area of Shanghai, China[J]. BMC Womens Health, 2023, 23(1):28.
[9] HE L L, LUO X P, BU Q W, et al. PAX1 and SEPT9 methylation analyses in cervical exfoliated cells are highly efficient for detecting cervical (pre)cancer in hrHPV-positive women[J]. J Obstet Gynaecol, 2023, 43(1):2179916.
[10] 李丽, 刘佳麒, 魏海波, 等. 保定地区育龄期妇女HPV感染状况及危险因素[J]. 贵州医科大学学报, 2022, 47(3):302-307.
[11] 韩朝娟, 韩燕媚, 张美龄, 等. 海口地区高危型HPV感染现状调查及相关风险因素分析[J]. 中国计划生育学杂志, 2021, 29(6):1088-1091, 1095.
[12] 邓再兴, 张闻雯. 湖州地区30958例女性感染高危型人乳头状瘤病毒检测结果分析[J]. 中国卫生检验杂志, 2018, 28(20):2472-2474.
[13] 邵文, 吴慧, 刘琼英, 等. 巴中地区女性体检人群HPV病毒感染情况及对宫颈病变发生率的影响[J]. 现代肿瘤医学, 2022, 30(2):286-289.
[14] 杨佳怡, 陈桂芳, 高运华, 等. HPV核酸检测标准物质研究进展[J]. 生物技术进展, 2020, 10(6):590-596.
[15] 余艳琴, 富诗岚, 徐慧芳, 等. 中国大陆女性体检人群中人乳头瘤病毒型别感染率及九价疫苗中HPV各型别分布的系统评价[J]. 肿瘤预防与治疗, 2019, 32(2):103-113.
[16] 赵宇倩, 赵方辉, 胡尚英, 等. 中国女性人群宫颈人乳头瘤病毒感染及型别分布的多中心横断面研究[J]. 中华流行病学杂志, 2015, 36(12):1351-1356.
[17] YUAN H W, LI R P, LV J, et al. Epidemiology of human papillomavirus on condyloma acuminatum in Shandong Province, China[J]. Hum Vaccin Immunother, 2023, 19(1):2170662.
[18] WATSON M, BENARD V, FLAGG E W. Assessment of trends in cervical cancer screening rates using healthcare claims data:united States, 2003-2014[J]. Prev Med Rep, 2018, 9:124-130.
[19] 郭雅琼, 刘科鹏, 赵彬, 等. 兰州市女性人乳头瘤病毒感染状况和基因型分布[J]. 国际检验医学杂志, 2021, 42(11):1372-1375, 1381.

邯郸市女性高危型HPV感染情况分析

Analysis of high-risk HPV infection results in Handan

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