不同粒径和来源大气颗粒物暴露与孕妇子痫前期发生风险的关联研究

doi:10.3969/j.issn.1004-616x.2024.03.002

癌变·畸变·突变 ›› 2024, Vol. 36 ›› Issue (3): 172-178.doi: 10.3969/j.issn.1004-616x.2024.03.002

不同粒径和来源大气颗粒物暴露与孕妇子痫前期发生风险的关联研究

李梦瑶¹, 邹晓璇², 徐洪兵¹, 赵银珠², 何兴侯¹, 杨海珊², 张彬¹, 王硕², 单旭阳¹, 刘海燕², 宋晓明¹, 杨英³, 黄薇¹

1. 北京大学公共卫生学院劳动卫生与环境卫生学系, 北京 100191;
2. 北京市海淀区妇幼保健院, 北京 100080;
3. 国家卫生健康委科学技术研究所, 北京 100081

收稿日期:2023-11-30 修回日期:2024-03-13 出版日期:2024-05-30 发布日期:2024-06-05
通讯作者: 黄薇, 杨英
作者简介:李梦瑶，E-mail：1710306109@pku.edu.cn。
基金资助:
北京市自然科学基金(7222246)

A retrospective analysis on the impact of size- and source-specific ambient particles on preeclampsia

LI Mengyao¹, ZOU Xiaoxuan², XU Hongbing¹, ZHAO Yinzhu², HE Xinghou¹, YANG Haishan², ZHANG Bin¹, WANG Shuo², SHAN Xuyang¹, LIU Haiyan², SONG Xiaoming¹, YANG Ying³, HUANG Wei¹

1. Department of Occupation and Environmental Health, School of Public Health, Peking University, Beijing 100191;
2. Haidian District Maternal and Child Health Care Hospital, Beijing 100080;
3. Institute of Science and Technology, National Health Commission, Beijing 100081, China

Received:2023-11-30 Revised:2024-03-13 Online:2024-05-30 Published:2024-06-05

摘要/Abstract

摘要： 目的：探究不同粒径和来源的大气颗粒物暴露对孕妇子痫前期发生风险的影响。方法：从北京市某城区妇幼保健院收集2014—2018年的产前检查记录；监测同期气象数据和空气动力学直径5~560 nm的大气颗粒物数浓度(PNC)，并应用正定矩阵因子分解法进行颗粒物的来源解析。采用Logistic回归分析大气颗粒物暴露与孕妇子痫前期发生风险的关联效应。结果：孕前3个月和孕早期暴露于空气动力学直径5~200 nm的颗粒物与孕妇子痫前期的发生存在正相关关系。孕前3个月的25~100 nm、100~200 nm粒径段的大气颗粒物暴露水平每增加四分位间距(IQR)浓度，子痫前期的发生风险分别增加36%[比值比(OR)=1.36，95%CI(1.04，1.76)]和40%[OR=1.40，95%CI(1.12，1.76)]；孕早期5~25 nm和100~200 nm粒径段的大气颗粒物暴露水平每增加IQR浓度，子痫前期的发生风险分别增加46%[OR=1.46，95%CI(1.15，1.83)]和40%[OR=1.40，95%CI(1.08，1.82)]。子痫前期发生风险与孕前3个月和孕早期的大气核模态颗粒和汽油车排放颗粒暴露存在显著关联。结论：大气颗粒物，特别是交通来源的细小粒径颗粒物暴露可增加孕妇子痫前期的发生风险。

关键词: 大气颗粒物, 超细颗粒物, 源解析, 子痫前期

Abstract: OBJECTIVE：This study aimed to examine the impact of size-segregated and source-specific ambient particles on preeclampsia risk. METHODS：This study was conducted based on the antenatal examination records from Maternal and Child Health Hospital from 2014-2018 in Beijing，China. Particle number concentrations (PNC) of particles in size fractions of 5-560 nm and meteorological data in this study area were collected. The sources of PNC_5-560 were apportioned using the positive matrix factorization method. Logistic regression was used to analyze associations between maternal exposure to ambient particles and preeclampsia risk. RESULTS：Maternal exposure to particles in size fractions of 5-200 nm during preconception and early pregnancy was associated with increased risk of preeclampsia. Per an interquartile range (IQR) increment in PNC_25-100 and PNC_100-200 exposure during preconception，the excess risks of PE increased by 36%[OR(odd ratio)=1.36，95%CI(1.04，1.76)] and 40%[OR=1.40，95%CI(1.12，1.76)]，respectively. Per an IQR increment in PNC_5-25 and PNC_100-200 exposure during early pregnancy，the excess risks of PE increased by 46%[OR=1.46，95%CI(1.15，1.83)] and 40%[OR=1.40，95%CI(1.08，1.82)]，respectively. Maternal exposure to nucleation and gasoline vehicle emissions during preconception and early pregnancy was associated with the risk of preeclampsia. CONCLUSION：Maternal exposure to traffic-related ultrafine particles during preconception and early pregnancy may increase the risk of preeclampsia.

Key words: ambient particle, ultrafine particles, source apportionment, preeclampsia

中图分类号:

R122

李梦瑶, 邹晓璇, 徐洪兵, 赵银珠, 何兴侯, 杨海珊, 张彬, 王硕, 单旭阳, 刘海燕, 宋晓明, 杨英, 黄薇. 不同粒径和来源大气颗粒物暴露与孕妇子痫前期发生风险的关联研究[J]. 癌变·畸变·突变, 2024, 36(3): 172-178.

LI Mengyao, ZOU Xiaoxuan, XU Hongbing, ZHAO Yinzhu, HE Xinghou, YANG Haishan, ZHANG Bin, WANG Shuo, SHAN Xuyang, LIU Haiyan, SONG Xiaoming, YANG Ying, HUANG Wei. A retrospective analysis on the impact of size- and source-specific ambient particles on preeclampsia[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2024, 36(3): 172-178.

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不同粒径和来源大气颗粒物暴露与孕妇子痫前期发生风险的关联研究

A retrospective analysis on the impact of size- and source-specific ambient particles on preeclampsia

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