关键词: 放射性肺损伤, 专利中药处方, 用药规律, 网络药理学

Abstract: OBJECTIVE：To collect the patent prescriptions of traditional Chinese medicine for the treatment of radiation-induced lung injury，and to understand their mechanisms of action. METHODS：The Chinese patent publication website of the State Intellectual Property Office Traditional Chinese medicine prescriptions for the treatment of radiation-induced lung injury was reviewed to collect relevant information and the data were correlated，clustered and subjected to complex networks analysis using the ancient and modern medical record cloud platform. The action targets and related pathways of the core prescription were investigated via network pharmacology. RESULTS：From the establishment of the database since August 2022，17 patents of Chinese medicine prescriptions (with 153 medicines) for the prevention and treatment of radiation-induced lung injury were filed. The most commonly used medicine included liquorice (9 times，52.94%) and Radix Rehmanniae (5 times，29.41%). Mechanistically，these Chinese medicine have been described as cold in four Qi，sweet in five flavor，lung in meridian，and heat clearing and detoxification in efficacy. The commonly used drug pairs are Radix Scrophulariae rehmanniae，bitter almond licorice，Houttuynia licorice，Radix Rehmanniae Scrophulariae. The core prescription consisted of licorice，Rehmannia glutinosa，bitter almond，Radix Scrophulariae and Houttuynia cordata. The main targets of the core prescriptions might be JUN，IL-6，PTGS2，FOS，IL-8，IL-10，etc. and the relevant action pathways included lipid and atherosclerosis，chemical carcinogenesis receptor activation，chemical carcinogenesis reactive oxygen species，PI3K Akt signaling pathway，MAPK signaling pathway，etc. CONCLUSION：Our investigation indicates that the therapeutic mechanism for the patent prescription of Chinese medicine was by clearing away heat and detoxification，cooling blood，supplementing spleen and Qi，and evacuating wind heat. The mechanism of action may be through inhibiting inflammatory reaction，thus alleviating radiation-induced lung injury.

Key words: radiation induced lung injury, patent Chinese medicine prescription, law of medication, network pharmacology