Abstract: BACKGROUND ＆ AIM:To study the influence of Mian_Zeng_Ling on mouse erythrocyte immunological function and Natural Killer(NK) cell activity. MATERIAL AND METHODS: The ratio of RBC_CR rosette,the ratio of RBC_IC rosette,the ratio of RBC_Ca rosette and NK cell activity were determined. RESULTS: Experiments showed mice erythrocytes could immunologically adhere to tumor cells. After peritoneal injection of cyclophosphamide,the ability of mice erythrocytes adhering to tumor cells was declined,Mian_Zeng_Ling could opposed this action,improving the adherent ability of erythrocytes. The effect of Mian_Zeng_Ling was superior to Zhen-Qi-Fu Zheng granlies sold in the market.Mian-Zeng-Ling also could oppose cyclophosphamide which reduced mouse NK cell activity,therefore improving and raising the activity of moccse NK cell. CONCLUSION: Mian_Zeng_Ling could improve erythrocyte immunological function and NK cell activity suppressed by cyclophosphamide.

Key words: Mian-Zeng-Ling, mouse, erythrocyte immunological function, natural killer cell activity