北京市超细颗粒物短期暴露与儿童肺炎发病风险的关联研究

doi:10.3969/j.issn.1004-616x.2025.01.001

Abstract

Abstract: OBJECTIVE： To investigate association between short-term exposure to size-specific ultrafine particles and risk of pediatric pneumonia. METHODS： Data between 2015—2020 were collected on emergency visits for pneumonia in children aged 0~14 years from Beijing Children's Hospital and China-Japan Friendship Hospital. Concurrent monitoring of particle number concentrations (PNC) in size fractions of 5-560 nm，conventional air pollutants，and meteorological data from fixed monitoring stations were collected. A time-stratified case-crossover study design and conditional logistic regression models were used to analyze associations between the exposure and pediatric emergency visits，with stratified analyses by age，gender，and season of visit. RESULTS： The short-term exposures were associated with increased risk of emergency visits for pneumonia in the children. An interquartile range (IQR) increment in PNC_5-25，PNC_25-100，PNC_100-560，and UFP exposure in the cumulative lag 0~7 days was associated with increased risks of emergency visits for pneumonia of 11.3% [OR=1.113，95%CI (1.063，1.164)]，21.8% [OR=1.218，95%CI (1.159，1.280)]，7.0% [OR=1.070，95%CI (1.037，1.104)]，and 20.0% [OR=1.200，95%CI (1.143，1.260)]，respectively. Stratified analysis showed that the effect of ambient particles on risk of the emergency visits was more pronounced during the cold season. For every interquartile range increase in the cumulative lag 0~7 days exposure concentration，the risk of pneumonia emergency visits rises by 24.2% [OR=1.242，95%CI (1.178，1.309)]. CONCLUSION： Short-term exposure to ambient particles in size fractions of 5-560 nm，particularly ultrafine particles，was associated with increased risk of pediatric pneumonia in urban area.

Key words: air pollution, ultrafine particles, children, pneumonia, morbidity risk

CLC Number:

R122

SHAN Xuyang, XU Hongbing, XU Huiying, GUAN Xinpeng, Fang Jiakun, WANG Tong, XU Baoping, ZHANG Qi, HUANG Wei. Association between short-term exposure to ultrafine particles and the risk of pneumonia among children in Beijing[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2025, 37(1): 1-7.

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Association between short-term exposure to ultrafine particles and the risk of pneumonia among children in Beijing

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