Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (1): 18-022.doi: 10.3969/j.issn.1004-616x.1998.01.007

Previous Articles     Next Articles

INHIBITORY EFFECT OF BIFIDOBACTERIUM BFIFIDUM AND ITS SURFACE MOLECULES ON DNA DAMAGE IN MURINE COLON MUCOSA BY MNNG

Lan J inggang , Hu Hong , Kang Gefei   

  1. Facul ty of L aboratory Medicine , Chongqing University of Medical Sciences . Chongqing , 　 S ichuan 　630046
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-01-30 Published:1998-01-30

PDF (PC)

2367

Abstract: Single cell gel elect rophoresis assay (SCGE) has the advantage of being a quick sensitive screening technique to elucidate various aspect s of toxic , genotoxic , and antigenotoxic activities by foreign compounds and nut ritional component s. Inhibitory effect of Bifidobacterium bifidum (Bif1101) and it s lipoteichoic acid(L TA) , whole cell peptidoglycan (WPG) , Spent culture (SC)on the DNA damage in murine colon mucosa by MNN G was investigated with SCGE. The results indicate that all the tested Bif1101 related materials appeared significant inhibition on the DNA damage by MNN G. The viable and dead Bif1101 whole cells appeared more effective than that of L TA and WPG. SC had slight effect . The methanism of the inhibitory effect of Bif1101 related materials on the DNA damage is probablly mediated by binding the MINN G and potentiating the immune activity so as to eliminate the MNN G complex or damaged cells.

Key words: Bifidobacterium bifidum, Lipoteichoic acid, Whole Cell Peptidoglycan, Antimutagenicity, MNNG