胆碱受体拮抗剂在小鼠骨髓细胞中的C- 有丝分裂效应研究

doi:10.3969/j.issn.1004-616x.1999.04.003

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1999, Vol. 11 ›› Issue (4): 165-167.doi: 10.3969/j.issn.1004-616x.1999.04.003

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C - MITOSIS INDUCTION BY ANTAGONISTS TO CHOLINERGIC RECEPTOR IN MOUSE BONE MARROW CELLS

He Zhijun , Li Xiaoqiong , Wang Xu

Department of L if e Sciences , Y unnan Normal University , Kunming 　650092

Received:1998-11-20 Revised:1999-03-17 Online:1999-07-30 Published:1999-07-30

Abstract

Abstract: The study investigated the C - mitotic effect s in mouse bone marrow cells induced by at ropine and dtubocurarine , which are antagonist s to muscarinic and nicotinic receptors , respectively. The doses used in the experiment s were 70 % LD50. The result s showed that the at ropine (highest dose , 5. 2mg/ kg) significantly induced increases of mitotic index(MI) and colchicine2mitotic frequency ( P < 0. 001 , P < 0. 05) , the f requency of anaphase was decreased ( P < 0. 001) . It is reqsonable to hypothesize that acetylcholine and it s receptor take part in the regulation of mitosis in mouse bone marrow cells. As C2mitotic effect s is a kind of sign for aneuploidy induction.

Key words: Antagonist s to acetylcholine receptor, C-mitosis, aneuploidy, mouse bone marrow cells

He Zhijun , Li Xiaoqiong , Wang Xu. C - MITOSIS INDUCTION BY ANTAGONISTS TO CHOLINERGIC RECEPTOR IN MOUSE BONE MARROW CELLS[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(4): 165-167.

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C - MITOSIS INDUCTION BY ANTAGONISTS TO CHOLINERGIC RECEPTOR IN MOUSE BONE MARROW CELLS

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