Carcinogenesis, Teratogenesis & Mutagenesis ›› 1999, Vol. 11 ›› Issue (4): 194-198.doi: 10.3969/j.issn.1004-616x.1999.04.011

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EVALUATION ON CARCINOGENIC RISK FROM ORGANIC POLLUTION IN THE S RIVER BY CELL TRANSFORMATION

Liu J iaren1 , Pang Yongxun1 , Zhang youen1 , Wang Xianzhen1 , Fan Chun1 , Zhu Zhengang1 , E. J . Love2   

  1. 1 Department of Envi ronmental Heal th of Harbin Medical University , Harbin 　150001 , 2Department of Com munity Heal th Sciences , Facul ty of Medicine , The University of Calgary . Canada
  • Received:1998-12-12 Revised:1999-04-06 Online:1999-07-30 Published:1999-07-30

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Abstract: NIH3T3 cell line was used for the study t ransformation induction by organic ext racts from water in the Sriver. The result indicated that the malignant t ransformed foci were induced by organic extract s mentioned above and the cellular transformation frequencies presented a dose-response relationship and determination of malignant cells disappeared in rest raining of contact and grew in culture of soft agar while cont rol cells did not .Thus , the present study demonst rates further that organic pollution f rom water in the S river has the potential risk of carcinogencity.

Key words: Organic pollution, NIH3T3 Cell t ransformation, Carcinogencity