铅对胎鼠中脑细胞增殖和分化的影响

doi:10.3969/j.issn.1004-616x.1999.05.016

Abstract

Abstract: Objective :To study the brain developmental toxicity of lead and it s relationship with cell proliferation and differentiation. Method :The rat embryonic midbrain micromass cult rue method was used to observe the effect of PbAc on brain cells proliferation and differetiation. Restults :The proliferation and differetiation of cultured cells were both inhibited by PbAc , and both effect s showed obvious dose2dependent decreases( P < 0. 05) . Concent rations of lead to inhibit cell proliferaion and differentiation by 50 % were 3. 69μmol ( ICp50) and 1. 03μmol ( ICd50) respectively. Conclusion :According to the standard of Flint , PbAc can be a specific inhibitor of rain cell differentiation , it s brain cell developmental toxicity is related to the inhibition of cell proliferation and ifferentiation.

Key words: Lead, Embryo midbrain neural cell, Micromass culture, Developmental toxicity, Rat

Fu Shaolian , Li Hong. EFFECTS OF LEAD ON RAT EMBRYO MIDBRAIN CELL PROLIFERATION AND DIFFERENTIATION[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(5): 249-251.

[1]	LIU Jianxin, MA Yuhong, HAO Weidong. Effects of sub-chronic exposure to cerium nitrate on neurobehavioral functions in SD rats [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(2): 81-87.
[2]	QU Ying, ZHOU Quan, CHEN Yifeng, YANG Yan, KANG Shuling, HE Chenzhou, JIANG Yu, WU Chuancheng, LIU Baoying, XIANG Jianjun. Relationships between particulate matter pollution and non-accidental deaths among residents in Fuzhou city before and after COVID-19 [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(2): 98-104.
[3]	LI Boru, QIN Shuangjian, CAI Ying, LI Runbing, GUAN Lan, XIAO Fang, ZENG Ming, XU Xinyun. Effects of PM_2.5 on invasion and migration abilities in three types of cancer cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(2): 124-128,133.
[4]	XU Wenli, HE Jiang, LI Shufang, WANG Xingang, ZHANG Yajuan, LIU Huan, YUE Juan, LI Jianguo, YANG Weijun. Reproductive toxicity of Capparis spinosa fruits pain gel paste in SD rats [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(2): 144-148.
[5]	SHI Wenjing, ZHANG Jiqianzhu, ZHU Jiangbo, ZHANG Xiaofang, WANG Ruina, DAI Xiaoyu, REN Lijun, TIAN Yijun. Evaluation of genotoxicity of diphenhydramine hydrochloride and caffeine compound [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(2): 149-153,157.
[6]	GUO Yufeng, KONG Xiaona, ZHANG Ting, ZHANG Chao, XUE Zhenwei, LI Jianjun, ZHANG Jing, ZHOU Xiaolin. Analysis of serum immunoglobulins among residents in the downwind direction of a coking plant in from 2015 to 2019 [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(1): 14-19.
[7]	ZHAO Yan, SUN Zhenxiao. Metformin inhibitd proliferation and migration of human breast cancer cell in vitro [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(1): 35-39.
[8]	YANG Yu, HUANG Yali, LIN Fei, TANG Long. Acute toxicity and genotoxicity of antitumor serum thymic factor 9 peptide [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(1): 57-61.
[9]	XIA Qiyue, YUE Qianlan, DOU Jiexiong, ZHUANG Siqi, LIU Keliang. Toxicological test of orally administered sodium sulfide in rats [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(1): 62-66.
[10]	DU Xiuming, HONG Liling, XU Lingzhi, ZHOU Qingyun. In vitro chromosome aberration evaluation of anatase titanium dioxide nanoparticles [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(1): 67-71.
[11]	WANG Xiaozhou, LI Hongshi, YU Xi, WEI Ning, WANG Ziying, HE Lijie. Effects of sinomenine on proliferation and invasion of HPV-positive cervical cancer SiHa cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(6): 442-445.
[12]	CHEN Hong, HUANG Yuanli, WANG Han, LIAN Huan, HAN Qianqian, WANG Chunren. Research on KeratinoSens assay applied to medical devices [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(6): 455-460.
[13]	LIU Ruiguo, CHEN Xiaoli, YOU Yingbin, LI Shufan, ZHANG Qingying. Relationships between dyslipidemia and serum levels of lead and cadmium in low school-aged children in a district of Shenzhen [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(6): 461-465.
[14]	ZHANG Zongming. Does thyroid microcarcinoma require surgery [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(5): 325-326.
[15]	YANG Xingxiao, ZHANG Xueyuan, ZOU Naiyi, SHAN Bao'en, MA Ming, ZHU Shuchai. Effects of HMGB1 silencing on migration, invasion and radiosensitivity of esophageal squamous cell carcinoma cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(5): 327-333.

EFFECTS OF LEAD ON RAT EMBRYO MIDBRAIN CELL PROLIFERATION AND DIFFERENTIATION

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments