Abstract: This study sought to address the relationship of breast carcinoma with deletion of MTS1 gene. 17 of 47 cases showed MTS1 gene was deleted by multiplex - PCR. The rate of deletion of MTS1 gene was 36. 2 %.the rate of deletion in metastatic breast carcinoma of lymph node was 60 %(9/ 15) , that in nonemetastatic breast carcinoma of lymph node was 25 %(8/ 32) . There were significant differences in the rate of deletion of MTS1 gene between them , and between the rate of infilt rating type of breast carcinoma and the others. These suggest that deletion of MTS1 gene was associated with progression and type of breast carcinoma.

Key words: PCR, Breast carcinoma, MTS1 gene