Carcinogenesis, Teratogenesis & Mutagenesis ›› 1999, Vol. 11 ›› Issue (6): 337-339.doi: 10.3969/j.issn.1004-616x.1999.06.017

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INFULENCES OF CALMODULIN ANTAGONIST ON HE EFFECTS OF CADMIUM IN BRAIN SYNAPTOSOME PROTEIN BIOSYNTHESIS OF MICE

Tang lingfang , Chen Yanmeng , Zhang Zhenling , SongLing , Yang Yongnian , Feng Zhiying   

  1. Department of Toxicology , Nanjing Medical University , Nanjing 　210029
  • Received:1999-07-26 Revised:1999-09-01 Online:1999-11-30 Published:1999-11-30

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Abstract: Abstract 　The isolated mice brain synaptosome was measured in vitro. The experiment explored protein biosynthesis by 3H - Leu in2 corporation technique , meanwhile , the influence of Calmodulin(CaM) inhibitor Chlorpromazine (CPZ) on this toxicity was investigated as well. The result indicated that Cd prevented 3H - Leu from incorporating into synaptosome , in which the concentration of Cd and the amount incorporated showed negative correlation and this toxic effect may be antagonized by CaM inibitor CPZ to some extend. It is concluded that CaM may be involved in the mechanism of Cd toxicity in brain synaptosome.

Key words: Key words 　Brain Synaptosome, Protein Biosynthesis, Calmodulin Inhibitor