肿瘤坏死因子在胆囊癌及结石组织中的表达

doi:10.3969/j.issn.1004-616x.2000.03.004

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2000, Vol. 12 ›› Issue (3): 139-142.doi: 10.3969/j.issn.1004-616x.2000.03.004

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EXPRESSION OF TUMOR NECROSIS FACTOR IN GALLSTONE AND GALLBLADDER CARCINOMA TISSUE

ZHOU Lian-suo1 , SHI Jing-sen2 , WANG Zuo-ren2 and WANG Lin2

(1. Department of A bdominal S urgery , A f f iliated Tumour Hospital , S hantou University Medical College ,Guangdong , S hantou 　515031 , China ; 2. Department of Hepatobilliary Surgery , First Affiliated Hospital , Xi’an Medical University , S hanxi , Xi’an 　710061 , China)

Received:2000-01-01 Revised:2000-03-17 Online:2000-07-30 Published:2000-07-30

Abstract

Abstract: Abstract : Purpose : To study the expression of TNF -αmRNA and TNF -αprotein in the development from hyperplasia , dysplasia to carcinoma of gallbladder mucosa and to discuss the pathogenesis of gallbladder mucosa and to discuss the pathogenesis of gallbladder carcinoma. Methods : In situ hybridization and immunohistochemist ry were used to detect the expression of TNF -αmRNA , TNF -αprotein in mucosa of hyperplasia , dysplasia and carcinoma of gallbladder. Results : ①The percentages of positive cells and the numbers of positive cells/per high power field (HPF) which expressed TNF - αmRNA in hyperplasia , dysplasia and carcinoma of gallbladder mucosa cell and mononuclear cells(MNC) were increasing. ②The numbers of carcinoma cells and MNC/ HPF which expressed TNF -αmRNA increased with increasing tumor grades and size. ③The pattern of TNF -αprotein expression was similar to that of TNF -αmRNA , but more f requent and widespread. ④There was a positive linear correlation between tumor cells and MNC of TNF -αmRNA and TNF -αexpression. Conclusion : TNF -αwas involved in the pathogenesis of gallbladder carcinoma induced by gallstone and the TNF -α expression in cancer cells may possibly be a marker for tumor staging.

Key words: Key words : gallbladder carcinoma, gallstone, mononuclear cells, immunohistochemist ry, in situ hybridization, tumor necrosis factor

CLC Number:

R735. 8

ZHOU Lian-suo , SHI Jing-sen , WANG Zuo-ren and WANG Lin. EXPRESSION OF TUMOR NECROSIS FACTOR IN GALLSTONE AND GALLBLADDER CARCINOMA TISSUE[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2000, 12(3): 139-142.

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EXPRESSION OF TUMOR NECROSIS FACTOR IN GALLSTONE AND GALLBLADDER CARCINOMA TISSUE

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