Abstract: Purpose and Methods : The mutagenicity and teratogenicity of stalk and leaf of Tri pterygium wilf ordii Hook . f ( TWHf ) were examined by chromosome aberration , micronucleus and teratogenic test s. Results : TWHf did not induce chromosome aberration and increase the f requency of micronuclei in mice , and had not significant teratogenicity. However , in high dose group it showed embryotoxicity , and the rates of fetal death obviously increased. Conclusion : Great attention should be paid when this drug is used for pregnant woman.

Key words: Tripterygium wilfordii Hook . F, mutagenicity, teratogenicity