Abstract: Purpose : To study the effect of the extract of Pleurotas sapidus on 4 tumor cell lines ( human hepatoma cell Q3 , human gastric cancer cell MGC-803 , human cervical carcinoma Hela cell , murine lung adenocar-cinoma cell SPC-A-1) . Methods : The survival cells and protein synthesis of tumor cell lines treated for 24 h with 10 - 1 g/ ml～10 - 6 g/ ml of the water and ethanol extracts from Pleurotas sapidus were determined by crystal violet staining and by Bradford assays. Results : ①There was a significant growth inhibition of tbe cell survival and protein synthesis of the cell lines at a dose of 10 - 1 g/ ml of the water and ethanol extracts ; ②The growth inhibition was found in different dose groups of ethanol extract . In the normal liver cells , the cell survival was not affected and the protein synthesis increased. Conclusion : The inhibition of the tumor cell lines with the extracts fom Pleurotas Sapidus may be related to the inhibition of cell growth and protein synthesis.

Key words: Pleurotas sapidus : in vit ro antitumor effect, cell growth, protein synthesis, Xinjiang