Carcinogenesis, Teratogenesis & Mutagenesis ›› 2002, Vol. 14 ›› Issue (2): 90-093.doi: 10.3969/j.issn.1004-616x.2002.02.007

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ALDEHYDE DEHYDROGENASE22 GENOTYPES AND DRINKING BEHAVIOROF CHINESE IN JIANGSU PROVINCE

WU Jian-zhong; DING Jian-hua; GAO Chang-ming; LI Su-ping; ZANG Yu; ZHOU Jian-nong; SU Ping;LIU Yan-ting;ZHOU Xue-fu; WANG Ru-hong; DING Bao-guo   

  1. Department of Epidemiology, Jiangsu Institute of Cancer Research, Nanjing 210009, China
  • Received:2001-07-31 Revised:2001-10-03 Online:2002-04-30 Published:2002-04-30
  • Contact: WU Jian-zhong

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Abstract: Purpose : To analyze the genotype frequency of aldehyde mdehydrogenase-2 (ALDH2) , and evaluate the relationship between ALDH2 polymorphism and drinking behavior in Chinese. Methods : Epidemiological data were collected from 273 healthy persons in Taixing city of Jiangsu province in China , and ALDH2 genotypes were detected by polymerase chain reaction-rest riction fragment length polymorphism (PCR2RFL P) . Results : The f requency of ALDH2 mutant allele was 47. 25 % in Chinese. No difference was found between ALDH2 1 and ALDH2 1 * 2/ ALDH2 2 in drinking f requency and alcohol consumption per occasion. Conclusion : The ALDH2 2 allele was relatively common in Chinese. Drinking behavior was not influenced by the individual genotypes of ALDH2.

Key words: aldehyde dehydrogenase22 (ALDH2), alcohol, aldehyde

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