葡萄籽原花青素对鼠伤寒沙门氏菌的抗诱变作用

doi:10.3969/j.issn.1004-616x.2002.03.016

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2002, Vol. 14 ›› Issue (3): 191-194.doi: 10.3969/j.issn.1004-616x.2002.03.016

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ANTIMUTAGENIC EFFECT OF PROCYANIDINS FROM VITIS VINIFERA SEED IN SALMONELLA TEST

SUN Zhi-guang1, ZHAO Wan2zhou2, LU Yin2, TANG Ling-fang3, ZHANG Zhen-ling3, ZHANG Shi-wei2

1. Department of Digestion, Hospital of TCM of Jiangsu Province, Nanjing 210029; 2. College of Traditional Chinese Herbs , Nanjing University of TCM; 3. Department of Toxicology, Nanjing Medical University

Received:2000-01-07 Revised:2002-04-20 Online:2002-07-30 Published:2002-07-30

Abstract

Abstract: Purpose : Antimutagenic effect of procyanidins f rom V itis vinif era seed was studied. Methods : A series of histidine2requiring st rains TA97 , TA98 , TA100 and TA102 were used for antimutagenicity test . Severalmutagenic agent s such as Sodium Azide (NaN3 ) , Mitomycine C (MMC) , Dexon , 2-AF , 1 , 8-Dihydroxyanthrachinon were used to make mutagenic model and antimutagenic effect s of procyanidins were observed. Every tester st rain was divided into model group , spontaneous mutation group and drug groups. Results : The result showed that procyanidins inhibited mutagenic effect s induced by the most of the model agent s , but little inhibitory effect was observed on TA102 reverse mutation induced by 1 ,82Dihydroxyanthrachinon ( + S9) . Conclusion : Antimutagenesis is one of mechanism chemoprevention of cancer of procyanidins.

Key words: Procyanidins, Vitis vinifera, antimutagenesis, Amestest, mutagen

CLC Number:

R961

SUN Zhi-guang, ZHAO Wanzhou, LU Yin, TANG Ling-fang, ZHANG Zhen-ling, ZHANG Shi-wei. ANTIMUTAGENIC EFFECT OF PROCYANIDINS FROM VITIS VINIFERA SEED IN SALMONELLA TEST[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2002, 14(3): 191-194.

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ANTIMUTAGENIC EFFECT OF PROCYANIDINS FROM VITIS VINIFERA SEED IN SALMONELLA TEST

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