Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (3): 183-185.doi: 10.3969/j.issn.1004-616x.2003.03.018

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THE MOUSE LYMPHOMA CELL MUTATION ASSAY

XIE Ming   

  1. Supervision and Test Center f or Pesticide Safety Evaluation and Quality Control ＆ Nation Research Center for New Drug Safty Evalution,Shenyang 110021,China
  • Received:2002-04-13 Revised:2002-11-25 Online:2003-07-30 Published:2003-07-30
  • Contact: XIE Ming

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Abstract: The mouse lymphoma cell mutation assay (shortened as the mouse lymphoma assay or MLA) is often used as a general genetic toxicological assay abroad in order to evaluate the genotoxicity risk. But MLA isn't much often reported in China. In this paper, the assay method and current protocol of MLA is not discussed and described. The areas discussed for MLA were only be on a typical microwell protocol. The method and procedure described were available and could be handled better according to the discription.

Key words: mouse lymph oma assay, mutagenicity test, 96－well microwell method