Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (2): 107-109.doi: 10.3969/j.issn.1004-616x.2004.02.013

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The Micronucleus Test of Meddroxyprogesterone Acetate in Bone Marroww Polychromatic Erythrocytes and Spermatogenic Cells of Malerats

JIA Yue; CUI Yu-gui; WANG Xing-hai; et al   

  1. Endocriology Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029,China
  • Received:2003-04-22 Revised:2003-06-04 Online:2004-03-30 Published:2004-03-30
  • Contact: JIA Yue

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Abstract: BACKGROUND ＆ AIM: To study the effect of Meddroxyprogesterone Acetate on the micronucleus rate in bone marrow polychromatic erythrocytes and spermatogenic cells of male rats. MATERIAL AND METHODS: 50 rats were classified into 4 groups. Each group received injection of saline (group C) or MPA(37.5, 75 and 150 mg/kg)(group P1, group P2 and group P3, respectively) for every month during 3 months. Data from sperm counting, sperm modality, and the micronucleus rate in bone marrow polychromatic erythrocytes and spermatogenic cells were collected and analysed. RESULTS: Spermatogenesis of rats undergoing administration of MPA had been suppressed. Testis of rats in group P1, P2 and P3 atrophied and sperm counting decreased remarkably compared with group C. There was no statistics difference of the micronucleus rate in bone marrow polychromatic erythrocytes between each group. The micronucleus rate in spermatogenic cells in group P2 and P3 raised, but resumed to normal after MPA deprived 9 months. CONCLUSION: MPA has no significant effect on increasing the incidence of the micronucleus rate in bone marrow polychromatic erythrocytes, while it can reversibly raise the micronucleus rate in spermatogenic cells.

Key words: Meddroxyprogesterone Acetate, male rats, bone marrow polychromatic erythrocytes, spermatogenic cells, micronucleus rate