Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (3): 134-136.doi: 10.3969/j.issn.1004-616x.2004.03.003

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The Integration of Human HBV Gene into the Genome of the Housefly

XU Li-yan，LI En-min, Liu Wei-quan，et al   

  1. Institute of Oncologic Pathology，Medical College of Shantou University ,Shantou 515031,China
  • Received:2003-10-15 Revised:2004-03-02 Online:2004-05-30 Published:2004-05-30
  • Contact: LI En-min

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Abstract: BACKGROUND ＆ AIM: To explore human Hapatitis B virus (HBV) gene integrated into the genome of the housefly. MATERIAL AND METHODS: The plasmid vector pHBVneo was constructed. Then the pHBVneo was transferred into eggs of housefly using electroporation. HBV gene was examined in the genome of DNAs from larvae of housefly by PCR. RESULS:HBV gene was detected in the genome from larvae of the transgenic housefly. CONCLUSION: HBV gene is able to integrate into the genome of the housefly.

Key words: HBV gene, housefly, gene integration