Abstract: BACKGROUND ＆ AIM:The character of hair dye causing cancer and causing mutation are increasingly getting attention.With the reports and references about different malignancy in blood system caused by hair dye in ten years, give more explaination about the relativity between hair dye with malignancy of blood system. MATERIAL AND METHODS: The report and references about malignancy in blood system in domestic and abroad. RESULTS: The reports of mutation character causing by permanence hair dye are variant in domestic and abroad. For the half-permanence hair dye, non-purification HCB1 is commonly considered having the character of causing mutation and cancer. After purification the character of causing mutation is greatly weaked, but the character of causing cancer have not changed. So non-purification of production is the reason of HCB1's character of causing mutation.HCB2 have the character of casuing mutation, but character of causing cancer can not be comfirmed. The paper report a case in which two different malignancy in blood system caused by hair dye occured in a patient. CONCLUSION: Using hair dye caused the rate of malignancy in blood system increasingly. 　　

Key words: hair dye, causing cancer, causing mutation, malignancy