Abstract: BACKGROUND ＆ AIM: To study oxidative injury of lung serum and liver in different time in mice after exposed to phosgene. MATERIAL AND METHODS: 40 mice were randomly divided into 4 groups with 10 mice in each.The mice in negative group were exposed to room air and the mice in positive group were exposed to 11.9 mg/L phosgene for 5 minutes,respectively. After 2 hours',4 hours',8 hours' exposure to phosgene,all mice were killed.The content of malondialdehyde(MDA) and reductive glutathione (GSH),activities of the total superoxide dismutase(T-SOD) in lung,serum and liver were determined. RESULTS: With the time prolonged after the mice were poisoned , MDA content in lung, serum and liver significantly increased(P<0.05);T-SOD activity significantly increased in lung(P<0.05);GSH content significantly decreased in mice lung and liver in negative group compared with that of negative group 2 hours after phosgene exposed(P<0.05). CONCLUSION: Phosgene can induce pulmonary edema and oxidative injury of lung serum and liver in mice.

Key words: phosgene, lung, oxidative injury