Carcinogenesis, Teratogenesis & Mutagenesis ›› 2005, Vol. 17 ›› Issue (3): 148-151.doi: 10.3969/j.issn.1004-616x.2005.03.006

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A Study on the NAT1 Genetic Polymorphism in the Lung Cancer Cases of Yunnan Population

WANG Xiao-yan;CHAN Ying;LIANG Zi-qing;CAO Neng;HUANG Yun-cao XIA ; Xiao-ling;WANG Xu   

  1. School of Life Sciences, Yunnan Normal University, Kunming 650092，Yunnan,China)
  • Received:2004-04-06 Revised:2004-11-10 Online:2005-05-30 Published:2005-05-30
  • Contact: WANG Xu

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Abstract: BACKGROUND ＆ AIM: To compare the allelic variants of NAT1 genes the wild-type alleles between lung cancer population and the normal populations of Yunnan province. MATERIAL AND METHODS: Polymerase chain reaction restriction-fragment length polymorphism (RCR-RFLP) and allele specific-PCR(AS-PCR) methods was emplyed to justify genotype of the aim population. RESULTS: The results show that there was no significant difference between and genotype frequencies between case and control population. CONCLUSION: Our date suggest that there wasn't relationship between the genotype and lung cancer in lung cancer population and the normal populations of Yunnan province.

Key words: gene polymorphism, N-acetyltransferase, lung cancer cases of Yunnan population, polymerase chain reaction restriction-fragment length polymorphism, allele specific-PCR