柑桔皮水提取液急性毒性和致突变性

doi:10.3969/j.issn.1004-616x.2005.06.018

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2005, Vol. 17 ›› Issue (6): 383-385.doi: 10.3969/j.issn.1004-616x.2005.06.018

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Studies on Acute Toxicity and Mutagenicity of Citrus Peel

DING Xiao-wen; CHEN Zong-dao

College of Food Science, Southwest Agricultural University

Received:2004-11-01 Revised:2005-01-20 Online:2005-11-30 Published:2005-11-30
Contact: DING Xiao-wen

Abstract

Abstract: BACKGROUND ＆ AIM: To study the acute toxicity and the mutagenicity of pummelo peel and orange peel. MATERIAL AND METHODS: The oral acute toxicity test in rats , Ames test, micronucleus test in bone marrow and sperm abnormality test were carried out. RESULTS: LD50 in rats of the pummelo peel and orange peel were more than 21.5 g/kg. The micronucleus rates and sperm abnormality rates in all doses were not significantly different from the control group. No increase in the number of revertant colonies was found in the Ames test with and without S9 mixture. CONCLUSION: Acute toxicity and the mutagenicity of pummelo peel and orange peel were not observed in this study.

Key words: Citrus peel, acute toxicity, mutagenicity

DING Xiao-wen, CHEN Zong-dao. Studies on Acute Toxicity and Mutagenicity of Citrus Peel[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2005, 17(6): 383-385.

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Studies on Acute Toxicity and Mutagenicity of Citrus Peel

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