Carcinogenesis, Teratogenesis & Mutagenesis ›› 2006, Vol. 18 ›› Issue (6): 469-471.doi: 10.3969/j.issn.1004-616x.2006.06.015

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DNA Damage Caused by Nonylphenol in Oyster Hemolymph Cells

LI Zheng-yan, WEI Dong   

  1. (1.Key Lab of Marine Environmental Science and Ecology,Ministry of Education,Ocean University of China,Qingdao 266003，Shandong;2.Faculty of Environmental Science ＆ Engineering, Ocean University of China, Qingdao 266003，Shandong,China)
  • Received:2005-09-05 Revised:2006-01-16 Online:2006-11-30 Published:2006-11-30
  • Contact: LI Zheng-yan

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Abstract: 【ABSTRACT】 BACKGROUND ＆ AIM：The effect of nonylphenol(NP) on DNA damage in oyster hemolymph cells was measured by single-cell gel electrophoresis assay in vivo. MATERIAL AND METHODS： Oysters were exposed to various NP concentrations (0, 0.025, 0.10, 0.25 and 1.00 mg/L) and DNA damage in hemolymph cells was assessed after 24 h and 48 h. RESULTS: NP at 0.025 mg/L caused slight damage to cellular DNA. The percentage of cellular damage was 6％ and 20％ after 24 h and 48 h, respectively. NP at 1.00 mg/L caused serious damage to cellular DNA. The percentage of cellular damage was 30％ and 60％ after 24 h and 48 h, respectively. CONCLUSION: NP causes genetic toxicity to oyster hemolymph cells.

Key words: single-cell gel electrophoresis, nonylphenol, oyster, DNA damage, genetic toxicity, hemolymph cell

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