苦瓜醇提取物对小鼠的急性经口毒性和遗传毒性试验研究

doi:10.3969/j.issn.1004-616x.2007.05.010

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2007, Vol. 19 ›› Issue (5): 381-383.doi: 10.3969/j.issn.1004-616x.2007.05.010

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Study on the Acute and Genetic Toxicities of Ethanol Extracts from Momordica Charantia

LIU Xiu_ying, HU Yi_xiu, YI Chuan_zhu, MA Zheng, HU Chun_sheng, YIN Jin

(Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China)

Received:2006-09-22 Revised:2006-11-27 Online:2007-09-30 Published:2007-09-30
Contact: LIU Xiu_ying

Abstract

Abstract: BACKGROUND ＆ AIM: To determine the acute oral toxicity and genetic toxicity of ethanol extracts from Momordica charantia(MC), so as to provide experimental basis for its exploitation. MATERIALS AND METHODS: The tests were performed according to GB159193_2003 Procedures and Methods for Toxicological Assessment of Food. RESULTS: The acute oral LD50 of ethanol extracts from Momordica charantia was greater than 21.5 g/kg. The genetic toxicity indicated by Ames test, micronucleus test of polychromatic erythrocytes in bone marrow and sperm shape abnormality test in mice was negative. CONCLUSION: In our experimental context, the acute toxicity of ethanol extracts from Momordica charantia was classified as non_toxic. Genetic toxicity was not found.

Key words: ethanol extracts from Momordica charantia, acute oral toxicity, genetic toxicity

CLC Number:

R994

LIU Xiu_ying, HU Yi_xiu, YI Chuan_zhu, MA Zheng, HU Chun_sheng, YIN Jin. Study on the Acute and Genetic Toxicities of Ethanol Extracts from Momordica Charantia[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2007, 19(5): 381-383.

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Study on the Acute and Genetic Toxicities of Ethanol Extracts from Momordica Charantia

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