胡椒碱的致突变作用

doi:10.3969/j.issn.1004-616x.2009.03.021

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2009, Vol. 21 ›› Issue (3): 241-242.doi: 10.3969/j.issn.1004-616x.2009.03.021

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The Mutagenicity of Piperine

LU Jing-kun, CHEN Zhao-jun, WANG Yu-hua，XIAO Yun-feng, LI Wen-yan

Pharmacy Department, Inner Mongolia Medical College, Hohhot 010059, China

Received:2008-07-10 Revised:2008-09-09 Online:2009-05-30 Published:2009-05-30

Abstract

Abstract: BACKGROUND AND AIM: To study the potential mutagenicity of piperine. MATERIALS AND METHODS: Micronucleus assay, chromosomal aberration test and sperm toxicity assay of mice were studied. RESULTS: The ratios of micronucleus cells with piperine 574 mg/kg ,287 mg/kg were increased compared with negative control .There were significant chromosomal damages with the piperine concentration of 574 mg/kg,287 mg/kg and notable sperm abnormalities with the piperine concentrations of 574 mg/kg,143 mg/kg compared with negative control. CONCLUSION: Piperine demonstrated mutagenicity in rats in this experimental system.

Key words: pepper alkali, mutagenicity

LU Jing-kun, CHEN Zhao-jun, WANG Yu-hua, XIAO Yun-feng, LI Wen-yan. The Mutagenicity of Piperine[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2009, 21(3): 241-242.

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The Mutagenicity of Piperine

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