Carcinogenesis, Teratogenesis & Mutagenesis ›› 2010, Vol. 22 ›› Issue (2): 130-133.doi: 10.3969/j.issn.1004-616x.2010.02.013

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Expressions of apolipoprotein M, liver receptor homolog-1 and hepatocyte nuclear factor-1α in hepatocellular carcinoma

CHENG Long-qiang1;ZHANG Yao2;CHEN Chang-jie2;YANG Qing-ling2;WANG Hui1   

  1. 1. Research Center of Clinical Laboratory;2. Department of Biochemistry ＆ Molecular Biology,Bengbu Medical College,Bengbu 233000, Anhui, China
  • Received:2009-09-23 Revised:2009-11-04 Online:2010-03-30 Published:2010-03-30
  • Contact: ZHANG Yao

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Abstract: OBJECTIVE: To explore the expressions of apolipoprotein M (apoM), liver receptor homolog-1(LRH-1) and hepatocyte nuclear factor-1α(HNF-1α) in hepatocellular carcinoma(HCC)tissue and para-cancer tissue，and analyze the associations among them. METHODS: The expressions of apoM,LRH-1, HNF-1α at the level of mRNA and apoM,HNF-1α at the level of protein were evaluated by RT-PCR and immunohistochemistry in the 17 primary HCC and para-cancer tissues. RESULTS: The expressions of apoM, LRH-1, HNF-1α mRNA and apoM,HNF-1α protein were obviously higher in HCC tissue than that in para-cancer tissue (P<0.01). LRH-1,HNF-1α showed significant positive correlation with the expression of apoM mRNA (r=0.463,P<0.01；r=0.356,P<0.05). CONCLUSION: Expression of apoM had close correlation with the expressions of LRH-1 and HNF-1α in HCC， and LRH-1 and HNF-1α may be the important regulatory factors of the apoM .

Key words: hepatocellular carcinoma, apolipoprotein M, liver receptor homolog-1, hepatocyte nuclear factor-1α

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