Carcinogenesis, Teratogenesis & Mutagenesis ›› 2010, Vol. 22 ›› Issue (4): 305-307.doi: 10.3969/j.issn.1004-616x.2010.04.014

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The anti-inflammatory effect and anti-oxidant activities of Shuangliao Houfeng San

CHEN Yi-cun1;TANG Zhao2;CAI Cong-yi1;QIN Yong-jie1   

  1. 1. Department of Pharmacology, Shantou University Medical College, Shantou 515041; 2. Guangdong Jiaying Pharmaceutical Co.,Ltd, Meizhou 514000, Guangdong, China
  • Received:2010-04-02 Revised:2010-05-28 Online:2010-07-30 Published:2010-07-30
  • Contact: CHEN Yi-cun

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Abstract: OBJECTIVE: This study was undertaken to ascertain the anti-inflammatory properties and antioxidant activities of Shuangliao Houfeng San(SHS). METHODS: Kunming mice were randomly divided into the control group, model group, and different concentration SHS groups. The anti-inflammatory effect of SHS was evaluated with croton oil-induced ear edema in mice and the increased levels of inflammatory mediators, nitric oxide (NO). The antioxidant activities were also studied on the effect on malondialdehyde(MDA) levels and enhancement of superoxide dismutase (SOD) activities. RESULTS: SHS produced significant inhibition on croton oil-induced ear edema in mice in a dose-dependent manner. SHS reduced the levels of NO and MDA, and enhanced the activities of SOD. CONCLUSION: SHS possesses potent anti-inflammatory properties and antioxidant activity.

Key words: shuangliao houfeng san, anti-inflammation, antioxidant, nitric oxide, superoxide dismutase, malondialdehyde

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