水蛭素冻干粉急性毒性和致突变性研究

doi:10.3969/j.issn.1004-616x.2010.04.016

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2010, Vol. 22 ›› Issue (4): 312-314.doi: 10.3969/j.issn.1004-616x.2010.04.016

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Study of acute toxicity and mutagenicity of lyophilizing hirudin powder

HUANG Chao-pei;ZHAO Peng;LI Bin;WANG Yan-wu;HE Li

Guangxi Center for Disease Prevention and Control, Nanning 530028, China

Received:2010-03-26 Revised:2010-05-14 Online:2010-07-30 Published:2010-07-30
Contact: HUANG Chao-pei

Abstract

Abstract: OBJECTIVE: To study acute oral toxicity and mutagenicity of lyophilizing hirudin powder. METHODS: Lyophilizing hirudin powder(50 AT-U/g)was given orally to mice to determine its acute oral toxicity, and mutagenicity was studied using Ames test, micronucleus test and sperm shape abnormality test. RESULTS: The oral LD50 of lyophilizing hirudin power in mice was more than 10.0 g/kg. No increase in the number of revertant colonies was found in the Ames test with and without S9 mixture. The micronucleus rates and sperm abnormality rates in all doses were not significantly different from the negative control. CONCLUSION: Lyophilizing hirudin powder showed no acute oral toxicity and mutagenicity.

Key words: lyophilizing hirudin powder, acute toxicity, mutagenicity

CLC Number:

R994.6

HUANG Chao-pei, ZHAO Peng, LI Bin, WANG Yan-wu, HE Li. Study of acute toxicity and mutagenicity of lyophilizing hirudin powder[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2010, 22(4): 312-314.

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Study of acute toxicity and mutagenicity of lyophilizing hirudin powder

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