AHNAK2蛋白在食管鳞癌中的表达及其临床意义

doi:10.3969/j.issn.1004-616x.2014.01.009

Abstract

Abstract:

OBJECTIVE: This study aimed to evaluate the expression and prognostic significance of AHNAK2 protein in esophageal squamous cell carcinoma (ESCC). METHODS：The alteration and clinical relevance of AHNAK2 protein levels were investigated in 129 ESCC cases by immunohistochemistry. RESULTS：The expression of AHNAK2 protein was up-regulated in some of ESCC tissues. Negative，weak，moderate and high expression of AHNAK2 were observed in 24.8% (32/129)，28.7% (37/129)，17.0% (22/129)，and 29.5% (38/129) of tumors，respectively. Positive expression of AHNAK2 was significantly correlated with tumor differentiation (P= 0.004). Kaplan-Meier survival curves showed that ESCC patients with negative expression of AHNAK2 had shorter overall survival time (P= 0.027). Cox regression analysis indicated that AHNAK2 protein expression was an independent prognostic factor (P= 0.018，HR = 0.461，95% CI：0.243-0.877). CONCLUSION：AHNAK2 was overexpressed in ESCC tissues and correlated with tumor differentiation. AHNAK2 expression might contribute to the prognostic evaluation of patients with this disease.

Key words: esophageal squamous cell carcinoma, AHNAK2, immunohistochemistry, tissue microarray, prognosis

LIU Hui-juan，SHANG Li，HAO Jia-jie，JIANG Yan-yi，SHI Feng，WANG Chun-li，ZHANG Yu，XU Xin，CAI Yan，HUANG Da-ke，JIA Xue-mei，WANG Ming-rong. Expression and clinical relevance of AHNAK2 in esophageal squamous cell carcinoma[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2014.01.009.

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Expression and clinical relevance of AHNAK2 in esophageal squamous cell carcinoma

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