Carcinogenesis, Teratogenesis & Mutagenesis
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WANG Bin-sheng
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OBJECTIVE: To study the significance of arginase-1 (Arg-1) in identifying primary hepatic carcinoma (PHC) and hepatic metastasis (HM). METHODS：Fine-needle aspiration biopsies (FNABs) were performed in 123 patients，cell block were made and immunohistochemical staining were applied. The expression of arginase-1 was measured. All patients received surgical resection and histopathologic diagnosis were obtained. Cytology，serum tumor markers，clinical and radiographic follow-up results were used for a final decision. The sensitivity and specificity of Arg-1 in identifying PHC and HM were calculated. RESULTS：123 patients diagnosed to have PHC (78 cases) or HM (45 cases). High expression was present in PHC group (83.3%) and stained strongly (60.3%). Positive expression rate of highly and moderately differentiated patients (92.9%) were higher than lowly differentiated patients (76.9%)，with no expression in cholangiocarcinoma patients. In the hybrid liver cancer patients the positive expression rate was 75%. In patients with HM，Arg-1 positive expression rate was low (8.9%) with weak staining，and were found in HM from colorectal cancer，pancreatic cancer. HM from other primary sites showed no Arg-1 positive expression. The sensitivity and specificity of Arg-1 in identifying PHC and HM were 83.3% and 91.1%，respectively. CONCLUSION： Arginase-1 may be a more sensitive marker of hepatocellular carcinoma (HCC) and hepatic metastasis. FNABs with Arg-1 immunohistochemical staining was sensitive and specific in identifying PHC and HM and warrant further promotion.
Key words: arginase-1, primary hepatic carcinoma, hepatic metastasis, fine-needle aspiration biopsy
WANG Bin-sheng. Effects of arginase-1 in identifying primary hepatocellular carcinoma and hepatic metastasis[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2014.02.007.
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