EZH2蛋白在人胎儿器官发育过程中的表达模式

doi:10.3969/j.issn.1004-616x.2014.04.002

Abstract

Abstract:

OBJECTIVE: To determine the expression pattern of EZH2 protein in the process of human fetal development and provide new and multi-organ information for understanding the possible roles of EZH2 during the whole fetal development. METHODS：33 human fetuses at 25 different gestational weeks and 1 neonatal sample were obtained through abortion or stillbirth. The organ or tissue including esophagus，stomach，small intestine，colon，liver， pancreas，parotid gland，thyroid，adrenal gland，lung，trachea，heart，large artery，kidney，bladder，uterus， ovary，testis，spleen，thymus，cerebrum were fixed，embedded，sectioned，then stained with hematoxylin and eosin to identify their morphological structures. Tissue microarrays were constructed and followed by immunohistochemical staining of EZH2. RESULTS：EZH2 was expressed in fetal organs investigated and exhibited different expression levels in different tissues and at various gestational ages. The positive staining of EZH2 protein was mainly located in the nucleus，as well as in the cytoplasm in some cells. CONCLUSION：EZH2 protein was generally expressed in human fetal organs and tissues and its expression exhibited tissue specificity and dependence on the stages of fetal development.

Key words: enhancer zeste homologue 2, fetus, development, expression pattern

LIU Shu-yan，ZHU Ning-xia，CHEN Hai-bin. Expression pattern of EZH2 in oganogenesis of human fetuses[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2014.04.002.

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Expression pattern of EZH2 in oganogenesis of human fetuses

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