Carcinogenesis, Teratogenesis & Mutagenesis ›› 2024, Vol. 36 ›› Issue (3): 172-178.doi: 10.3969/j.issn.1004-616x.2024.03.002

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A retrospective analysis on the impact of size- and source-specific ambient particles on preeclampsia

LI Mengyao1, ZOU Xiaoxuan2, XU Hongbing1, ZHAO Yinzhu2, HE Xinghou1, YANG Haishan2, ZHANG Bin1, WANG Shuo2, SHAN Xuyang1, LIU Haiyan2, SONG Xiaoming1, YANG Ying3, HUANG Wei1   

  1. 1. Department of Occupation and Environmental Health, School of Public Health, Peking University, Beijing 100191;
    2. Haidian District Maternal and Child Health Care Hospital, Beijing 100080;
    3. Institute of Science and Technology, National Health Commission, Beijing 100081, China
  • Received:2023-11-30 Revised:2024-03-13 Online:2024-05-30 Published:2024-06-05

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Abstract: OBJECTIVE：This study aimed to examine the impact of size-segregated and source-specific ambient particles on preeclampsia risk. METHODS：This study was conducted based on the antenatal examination records from Maternal and Child Health Hospital from 2014-2018 in Beijing，China. Particle number concentrations (PNC) of particles in size fractions of 5-560 nm and meteorological data in this study area were collected. The sources of PNC5-560 were apportioned using the positive matrix factorization method. Logistic regression was used to analyze associations between maternal exposure to ambient particles and preeclampsia risk. RESULTS：Maternal exposure to particles in size fractions of 5-200 nm during preconception and early pregnancy was associated with increased risk of preeclampsia. Per an interquartile range (IQR) increment in PNC25-100 and PNC100-200 exposure during preconception，the excess risks of PE increased by 36%[OR(odd ratio)=1.36，95%CI(1.04，1.76)] and 40%[OR=1.40，95%CI(1.12，1.76)]，respectively. Per an IQR increment in PNC5-25 and PNC100-200 exposure during early pregnancy，the excess risks of PE increased by 46%[OR=1.46，95%CI(1.15，1.83)] and 40%[OR=1.40，95%CI(1.08，1.82)]，respectively. Maternal exposure to nucleation and gasoline vehicle emissions during preconception and early pregnancy was associated with the risk of preeclampsia. CONCLUSION：Maternal exposure to traffic-related ultrafine particles during preconception and early pregnancy may increase the risk of preeclampsia.

Key words: ambient particle, ultrafine particles, source apportionment, preeclampsia

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