中草药保健香烟的减毒及抗突变作用初步研究

doi:10.3969/j.issn.1004-616x.2007.01.021

癌变·畸变·突变 ›› 2007, Vol. 19 ›› Issue (1): 70-072.doi: 10.3969/j.issn.1004-616x.2007.01.021

中草药保健香烟的减毒及抗突变作用初步研究

韦献飞；唐荣兰；甘运生；罗凤姣

柳州医学高等专科学校　广西　柳州　545006

收稿日期:2006-02-16 修回日期:2006-10-08 出版日期:2007-01-30 发布日期:2007-01-30

The Toxicity Attenuation and Antimutagenic Effect of Health- preserving Cigarettes Made From Chinese Herbal Medicine

WEI Xian-fei，TANG Rong-lan，GAN Yun-sheng，LUO Feng-jiao

Liuzhou Medical College, Liuzhou, Guangxi 545006, China

Received:2006-02-16 Revised:2006-10-08 Online:2007-01-30 Published:2007-01-30

摘要/Abstract

摘要： 背景与目的：探讨中草药保健香烟的降毒作用和抗突变作用。材料与方法：在香烟中加入中草药假　等制成中草药保健香烟，用该香烟制得生理盐水烟雾液为实验材料，进行小鼠急性毒性实验、小鼠骨髓嗜多染红细胞(PCE)微核试验和Ames试验。结果：小鼠急性毒性实验的半数致死剂量(LD50)保健香烟组比原香烟对照组增加了4～5倍；小鼠骨髓嗜多染红细胞微核率为6‰～10‰，明显低于原香烟对照组(16‰～28‰)，并有剂量-效应关系(r=0.9554)；Ames试验细菌回变数量比原香烟对照组可减少69％～83％，并同时存在剂量-效应关系(r=0.9843)。结论：中草药保健香烟能大幅度降低香烟的毒性和致突变作用。

关键词: 中草药, 假, 保健香烟, 抗突变

Abstract: BACKGROUND ＆ AIM: To study the toxicity attenuation and antimutagenic effects of health-preserving cigarettes made from Chinese herbal medicine. MATERLALS AND METHODS: The health-preserving cigarettes were made by certain Chinese herbal medicine such as piper sarmentosum Roxb. We made these cigarettes into a smoke liquid of normal saline solution as an experimental material to do an acute toxicity test in mice.A micronucleus test of mice bone marrow polychromatophilic erythroblast(PCE) and an Ames test were performed. RESULTS: The LD50 of mice in the acute toxicity test was four to five times more than the control group. The micronucleus test of PCE in the mice bone marrow was 6‰～10‰, obviously lower than the original control group(16‰～28‰) with a dose-effect relationship(r=0.9554). In the Ames test，the number of the bacterial mutagenesis could be reduced 69％～83％ of that in the control group,also with a dose-effect relationship(r=0.9843). CONCLUSION: Health-preserving cigarettes made from Chinese herbal medicine could greatly lower the toxicity of cigarettes，and have obvious antimutagenic effect.

Key words: Chinese herbal medicine, piper sarmentosum Roxb., health-preserving cigarettes, antimutagenicity

中图分类号:

R394.6

韦献飞, 唐荣兰, 甘运生, 罗凤姣. 中草药保健香烟的减毒及抗突变作用初步研究[J]. 癌变·畸变·突变, 2007, 19(1): 70-072.

WEI Xian-fei, TANG Rong-lan, GAN Yun-sheng, LUO Feng-jiao. The Toxicity Attenuation and Antimutagenic Effect of Health- preserving Cigarettes Made From Chinese Herbal Medicine[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2007, 19(1): 70-072.

[1]	王冲，侯娟，韩晶，芮菁*. 藏茵陈总萜酮的致突变及抗突变作用[J]. 癌变·畸变·突变, 2014, 26(3): 221-224.
[2]	温居一, 张积仁, 李　鹏, 张　军, 王　斌. NADH对二乙基亚硝胺所致L02人肝细胞株p53基因突变和c-erbB2基因表达的影响[J]. 癌变·畸变·突变, 2009, 21(5): 329-333.
[3]	宋文涛, 马志敏, 季守莲, 刘光明, 施贵荣. 蚕豆根尖微核技术测定美洲大蠊和九香虫混合成分的抗突变性[J]. 癌变·畸变·突变, 2008, 20(6): 475-476.
[4]	贺小琼1；普苹2 ；邓艳1；段生朝1. 真菌植物提取物AMH抑制苯并(a)芘诱发小鼠肿瘤作用[J]. , 2006, 18(3): 205-207.
[5]	王明臣1;张善锋1;毛红丽2;金国平1;董子明1. Ames实验对叶黄素的致突变性与抗突变性研究[J]. , 2006, 18(1): 65-067.
[6]	马中春. 葡萄籽提取物的抗突变试验[J]. , 2005, 17(5): 306-307.
[7]	张世敏，魏会平，杨春玫，田翠时，李继红. 针灸抗突变效应的实验研究[J]. , 2004, 16(4): 239-241.
[8]	付小梅，高淑清，孙　侠综　述　单保恩, 审校. 裙带菜的生理药理作用研究进展[J]. , 2004, 16(4): 254-256.
[9]	贺小琼;陈彦红;熊祥玲. 真菌植物松茸提取物体外抑制卷烟焦油致突变作用[J]. , 2004, 16(1): 46-49.
[10]	南晓光. 麦饭石浸液抑制白酒和香烟诱发蚕豆根尖细胞微核的研究[J]. , 2004, 16(1): 50-51.
[11]	袁振华，丁友昌. 浙江几种传统腌制食品的致突变性及抗突变研究[J]. , 2003, 15(2): 91-93.
[12]	张春玲，胡俊峰，曲江斌，袁晓燕. 几种中草药及绿茶对B(a)P和NNK的抗诱变作用[J]. , 2003, 15(2): 101-103.
[13]	邓丽霞1, 胡　斌1, 陈小君2, 陈铁江1, 甘德秀1, 郑履康1, 范瑞泉1. 萌动激活赤灵芝孢子粉致畸、致突变和抗突变的实验研究①[J]. , 2002, 14(3): 183-185.
[14]	郭　炜1;赵泽贞1;单保恩2;魏丽珍1,温登瑰1. 六种中草药抗突变及抗肿瘤活性的实验报告[J]. , 2002, 14(2): 94-097.
[15]	赵泽贞;魏丽珍;温登瑰;郭　炜. 樱桃等4 种水果的抗突变性初步实验研究[J]. , 2002, 14(2): 110-111.

中草药保健香烟的减毒及抗突变作用初步研究

The Toxicity Attenuation and Antimutagenic Effect of Health- preserving Cigarettes Made From Chinese Herbal Medicine

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价